A 2-Year, Randomized, Clinical Trial Examining the Effects of Speed of Processing Cognitive Training on Quality-of-Life Indicators in Adults With HIV-Associated Neurocognitive Disorder in Birmingham, Alabama: Results of the Think Fast Study

David E. Vance, Pariya L. Fazeli, Andres Azuero, Jennifer S. Frank, Virginia G. Wadley, Raper L. James, Caitlin N. Pope, Alexandra Jacob, Karlene K. Ball

Research output: Contribution to journalArticlepeer-review

Abstract

Speed of processing (SOP) cognitive training may improve indicators of the quality of life (QoL) in people living with HIV. In this 2-year, longitudinal, randomized, controlled trial, 216 participants ages 40 years and older with HIV-associated neurocognitive disorder or borderline HIV-associated neurocognitive disorder were assigned to one of three groups: (a) 10 hr of SOP training (n = 70); (b) 20 hr of SOP training (n = 73), or (c) 10 hr of internet navigation control training (a contact control group; n = 73). Participants completed several QoL measures at baseline, posttest, and Year 1 and Year 2 follow-ups. Using linear mixed-effect models, no strong pattern of training effects across QoL outcomes was apparent, with small-magnitude, nonsignificant, between-group differences in depression, locus of control, and Medical Outcomes Study-HIV scales. In conclusion, despite prior work showing some transfer of SOP cognitive training improving QoL, that was not observed. Implications for research and practice are posited.

Original languageEnglish
Pages (from-to)104-121
Number of pages18
JournalJournal of the Association of Nurses in AIDS Care
Volume35
Issue number2
DOIs
StatePublished - Mar 1 2024

Bibliographical note

Publisher Copyright:
© 2024 Lippincott Williams and Wilkins. All rights reserved.

Keywords

  • brain fitness
  • cognitive impairment
  • cognitive remediation
  • cognitive reserve
  • cognitive training
  • neuroplasticity

ASJC Scopus subject areas

  • Advanced and Specialized Nursing

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