TY - JOUR
T1 - A 2-Year, Randomized, Clinical Trial Examining the Effects of Speed of Processing Cognitive Training on Quality-of-Life Indicators in Adults With HIV-Associated Neurocognitive Disorder in Birmingham, Alabama
T2 - Results of the Think Fast Study
AU - Vance, David E.
AU - Fazeli, Pariya L.
AU - Azuero, Andres
AU - Frank, Jennifer S.
AU - Wadley, Virginia G.
AU - James, Raper L.
AU - Pope, Caitlin N.
AU - Jacob, Alexandra
AU - Ball, Karlene K.
N1 - Publisher Copyright:
© 2024 Lippincott Williams and Wilkins. All rights reserved.
PY - 2024/3/1
Y1 - 2024/3/1
N2 - Speed of processing (SOP) cognitive training may improve indicators of the quality of life (QoL) in people living with HIV. In this 2-year, longitudinal, randomized, controlled trial, 216 participants ages 40 years and older with HIV-associated neurocognitive disorder or borderline HIV-associated neurocognitive disorder were assigned to one of three groups: (a) 10 hr of SOP training (n = 70); (b) 20 hr of SOP training (n = 73), or (c) 10 hr of internet navigation control training (a contact control group; n = 73). Participants completed several QoL measures at baseline, posttest, and Year 1 and Year 2 follow-ups. Using linear mixed-effect models, no strong pattern of training effects across QoL outcomes was apparent, with small-magnitude, nonsignificant, between-group differences in depression, locus of control, and Medical Outcomes Study-HIV scales. In conclusion, despite prior work showing some transfer of SOP cognitive training improving QoL, that was not observed. Implications for research and practice are posited.
AB - Speed of processing (SOP) cognitive training may improve indicators of the quality of life (QoL) in people living with HIV. In this 2-year, longitudinal, randomized, controlled trial, 216 participants ages 40 years and older with HIV-associated neurocognitive disorder or borderline HIV-associated neurocognitive disorder were assigned to one of three groups: (a) 10 hr of SOP training (n = 70); (b) 20 hr of SOP training (n = 73), or (c) 10 hr of internet navigation control training (a contact control group; n = 73). Participants completed several QoL measures at baseline, posttest, and Year 1 and Year 2 follow-ups. Using linear mixed-effect models, no strong pattern of training effects across QoL outcomes was apparent, with small-magnitude, nonsignificant, between-group differences in depression, locus of control, and Medical Outcomes Study-HIV scales. In conclusion, despite prior work showing some transfer of SOP cognitive training improving QoL, that was not observed. Implications for research and practice are posited.
KW - brain fitness
KW - cognitive impairment
KW - cognitive remediation
KW - cognitive reserve
KW - cognitive training
KW - neuroplasticity
UR - http://www.scopus.com/inward/record.url?scp=85185768111&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85185768111&partnerID=8YFLogxK
U2 - 10.1097/JNC.0000000000000449
DO - 10.1097/JNC.0000000000000449
M3 - Article
C2 - 38949906
AN - SCOPUS:85185768111
SN - 1055-3290
VL - 35
SP - 104
EP - 121
JO - Journal of the Association of Nurses in AIDS Care
JF - Journal of the Association of Nurses in AIDS Care
IS - 2
ER -