A base induced fragmentation of tetramisole

Richard F. Fibiger, Allen R. Banks, Ted Jones, R. Curtis Haltiwanger, David S. Watt

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The exposure of dl‐2,3,5,6‐tetrahydro‐6‐phenylimidazo[2,1‐6 Jthiazole (tetramisole) to lithium diisopropylamide in tetrahydrofuran ruptures the thiazole ring to give, following the introduction of primary or secondary alkyl halides, 1‐(2′‐alkylthio)ethyl‐4‐phenylimidazoles. Conclusive evidence for the thiazole ring opening was obtained by a single crystal x‐ray diffraction study of 1‐(2′‐p‐bromobenzylthio)ethyl‐4‐phenylimidazole.

Original languageEnglish
Pages (from-to)307-310
Number of pages4
JournalJournal of Heterocyclic Chemistry
Issue number2
StatePublished - Mar 1978

ASJC Scopus subject areas

  • Organic Chemistry


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