The exposure of dl‐2,3,5,6‐tetrahydro‐6‐phenylimidazo[2,1‐6 Jthiazole (tetramisole) to lithium diisopropylamide in tetrahydrofuran ruptures the thiazole ring to give, following the introduction of primary or secondary alkyl halides, 1‐(2′‐alkylthio)ethyl‐4‐phenylimidazoles. Conclusive evidence for the thiazole ring opening was obtained by a single crystal x‐ray diffraction study of 1‐(2′‐p‐bromobenzylthio)ethyl‐4‐phenylimidazole.
|Number of pages||4|
|Journal||Journal of Heterocyclic Chemistry|
|State||Published - Mar 1978|
ASJC Scopus subject areas
- Organic Chemistry