Abstract
The exposure of dl‐2,3,5,6‐tetrahydro‐6‐phenylimidazo[2,1‐6 Jthiazole (tetramisole) to lithium diisopropylamide in tetrahydrofuran ruptures the thiazole ring to give, following the introduction of primary or secondary alkyl halides, 1‐(2′‐alkylthio)ethyl‐4‐phenylimidazoles. Conclusive evidence for the thiazole ring opening was obtained by a single crystal x‐ray diffraction study of 1‐(2′‐p‐bromobenzylthio)ethyl‐4‐phenylimidazole.
| Original language | English |
|---|---|
| Pages (from-to) | 307-310 |
| Number of pages | 4 |
| Journal | Journal of Heterocyclic Chemistry |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1978 |
ASJC Scopus subject areas
- Organic Chemistry
Fingerprint
Dive into the research topics of 'A base induced fragmentation of tetramisole'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver