TY - JOUR
T1 - A bioluminescent molecular switch for glucose
AU - Teasley Hamorsky, Krystal
AU - Ensor, C. Mark
AU - Wei, Yinan
AU - Daunert, Sylvia
PY - 2008/5/5
Y1 - 2008/5/5
N2 - (Figure Presented) Glowing after a sugar rush: A molecular switch is formed by inserting glucose-binding protein (GBP) into aequorin (AEQ; see picture). This switch is triggered by recognition of glucose by the GBP. For the first time, AEQ is rationally split into two fragments that, upon a molecular recognition event, come together and emit bioluminescence.
AB - (Figure Presented) Glowing after a sugar rush: A molecular switch is formed by inserting glucose-binding protein (GBP) into aequorin (AEQ; see picture). This switch is triggered by recognition of glucose by the GBP. For the first time, AEQ is rationally split into two fragments that, upon a molecular recognition event, come together and emit bioluminescence.
KW - Binding proteins
KW - Luminescence
KW - Molecular switches
KW - Photoproteins
KW - Protein engineering
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U2 - 10.1002/anie.200704440
DO - 10.1002/anie.200704440
M3 - Article
C2 - 18383457
AN - SCOPUS:45549101342
SN - 1433-7851
VL - 47
SP - 3718
EP - 3721
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 20
ER -