A brief instrument to assess treatment response in the patient with advanced alzheimer disease

Frederick A. Schmitt, Judith A. Saxton, Yikang Xu, Thomas McRae, Yijun Sun, Sharon Richardson, Honglan Li

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The availability of effective treatments for severe Alzheimer disease (AD) has accentuated the need for brief, simple tools to evaluate treatment response in busy clinical settings for patients with advanced dementia. To develop such a tool, data on 875 patients from 4 double-blind-randomized studies of donepezil in severe AD [Mini-Mental State Examination (MMSE) 0 to 12 inclusive] were pooled and analyzed to identify Severe Impairment Battery (SIB) items, which are sensitive to change over time. Eight of the 51 SIB items were chosen based on effect sizes and relative ease of administration. The resulting SIB-8 was then applied to a validation data set (not used to generate the short form) to characterize its usefulness. The items, Month, Months of Year, Write Name, Sentence, Fluency, Confrontational Naming-Spoon, Using Spoon-Photograph, and Digit Span, were sensitive to change with treatment (P<0.0001) and easy to administer. Baseline SIB-8 scores were correlated with baseline MMSE and full-scale SIB scores, and provided a good distribution of scores in patients at the lower end of the MMSE. The SIB-8 is a brief (≤3min) assessment for patients with severe AD that is sensitive to change and able to detect treatment response.

Original languageEnglish
Pages (from-to)377-383
Number of pages7
JournalAlzheimer Disease and Associated Disorders
Issue number4
StatePublished - Oct 2009


  • Alzheimer disease
  • Assessment
  • Severe

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


Dive into the research topics of 'A brief instrument to assess treatment response in the patient with advanced alzheimer disease'. Together they form a unique fingerprint.

Cite this