TY - JOUR
T1 - A clinical trial to validate event-related potential markers of Alzheimer's disease in outpatient settings
AU - Cecchi, Marco
AU - Moore, Dennis K.
AU - Sadowsky, Carl H.
AU - Solomon, Paul R.
AU - Doraiswamy, P. Murali
AU - Smith, Charles D.
AU - Jicha, Gregory A.
AU - Budson, Andrew E.
AU - Arnold, Steven E.
AU - Fadem, Kalford C.
N1 - Publisher Copyright:
© 2015 The Authors.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Introduction: We investigated whether event-related potentials (ERP) collected in outpatient settings and analyzed with standardized methods can provide a sensitive and reliable measure of the cognitive deficits associated with early Alzheimer's disease (AD). Methods: A total of 103 subjects with probable mild AD and 101 healthy controls were recruited at seven clinical study sites. Subjects were tested using an auditory oddball ERP paradigm. Results: Subjects with mild AD showed lower amplitude and increased latency for ERP features associated with attention, working memory, and executive function. These subjects also had decreased accuracy and longer reaction time in the target detection task associated with the ERP test. Discussion: Analysis of ERP data showed significant changes in subjects with mild AD that are consistent with the cognitive deficits found in this population. The use of an integrated hardware/software system for data acquisition and automated data analysis methods make administration of ERP tests practical in outpatient settings.
AB - Introduction: We investigated whether event-related potentials (ERP) collected in outpatient settings and analyzed with standardized methods can provide a sensitive and reliable measure of the cognitive deficits associated with early Alzheimer's disease (AD). Methods: A total of 103 subjects with probable mild AD and 101 healthy controls were recruited at seven clinical study sites. Subjects were tested using an auditory oddball ERP paradigm. Results: Subjects with mild AD showed lower amplitude and increased latency for ERP features associated with attention, working memory, and executive function. These subjects also had decreased accuracy and longer reaction time in the target detection task associated with the ERP test. Discussion: Analysis of ERP data showed significant changes in subjects with mild AD that are consistent with the cognitive deficits found in this population. The use of an integrated hardware/software system for data acquisition and automated data analysis methods make administration of ERP tests practical in outpatient settings.
KW - Automated ERP data analysis
KW - Early stage Alzheimer's disease
KW - Event-related potentials
KW - Multicenter clinical trial
KW - Oddball paradigm
KW - Outpatient settings
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U2 - 10.1016/j.dadm.2015.08.004
DO - 10.1016/j.dadm.2015.08.004
M3 - Article
AN - SCOPUS:84945403422
VL - 1
SP - 387
EP - 394
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
IS - 4
ER -
