A clinical trial to validate event-related potential markers of Alzheimer's disease in outpatient settings

Marco Cecchi, Dennis K. Moore, Carl H. Sadowsky, Paul R. Solomon, P. Murali Doraiswamy, Charles D. Smith, Gregory A. Jicha, Andrew E. Budson, Steven E. Arnold, Kalford C. Fadem

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Introduction: We investigated whether event-related potentials (ERP) collected in outpatient settings and analyzed with standardized methods can provide a sensitive and reliable measure of the cognitive deficits associated with early Alzheimer's disease (AD). Methods: A total of 103 subjects with probable mild AD and 101 healthy controls were recruited at seven clinical study sites. Subjects were tested using an auditory oddball ERP paradigm. Results: Subjects with mild AD showed lower amplitude and increased latency for ERP features associated with attention, working memory, and executive function. These subjects also had decreased accuracy and longer reaction time in the target detection task associated with the ERP test. Discussion: Analysis of ERP data showed significant changes in subjects with mild AD that are consistent with the cognitive deficits found in this population. The use of an integrated hardware/software system for data acquisition and automated data analysis methods make administration of ERP tests practical in outpatient settings.

Original languageEnglish
Pages (from-to)387-394
Number of pages8
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Issue number4
StatePublished - Dec 1 2015

Bibliographical note

Publisher Copyright:
© 2015 The Authors.


  • Automated ERP data analysis
  • Early stage Alzheimer's disease
  • Event-related potentials
  • Multicenter clinical trial
  • Oddball paradigm
  • Outpatient settings

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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