A closed-loop model of the ovine cardiovascular system

J. Qian, J. W. Clark, K. Lu, F. Ghorbel, J. B. Zwischenberger, A. Bidani

Research output: Contribution to journalConference articlepeer-review


Sheep can be used as an important animal model for studying human cardiovascular and pulmonary disease. We develop a mathematical closed-loop model of the ovine cardiovascular system. A distributed approach is adopted in describing the systemic circulation, which is divided into the cerebral, coronary, foreleg, thoracic, abdominal, and hind limb circulations. A similar model is developed for the pulmonary circulation. The integrated model addresses problems of cardiovascular interaction, neural feedback control, and volume regulation among different organs. It facilitates a better understanding of the cardiovascular system in sheep and yields insights into cardiovascular and cardiopulmonary diseases. We apply the model to study cardiovascular interactions induced via orthostatic stress.

Original languageEnglish
Pages (from-to)1585-1586
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
StatePublished - 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002


  • Cardiovascular model
  • Orthostatic stress
  • Postural change
  • Sheep

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics


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