Abstract
Sheep can be used as an important animal model for studying human cardiovascular and pulmonary disease. We develop a mathematical closed-loop model of the ovine cardiovascular system. A distributed approach is adopted in describing the systemic circulation, which is divided into the cerebral, coronary, foreleg, thoracic, abdominal, and hind limb circulations. A similar model is developed for the pulmonary circulation. The integrated model addresses problems of cardiovascular interaction, neural feedback control, and volume regulation among different organs. It facilitates a better understanding of the cardiovascular system in sheep and yields insights into cardiovascular and cardiopulmonary diseases. We apply the model to study cardiovascular interactions induced via orthostatic stress.
| Original language | English |
|---|---|
| Pages (from-to) | 1585-1586 |
| Number of pages | 2 |
| Journal | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Volume | 2 |
| State | Published - 2002 |
| Event | Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States Duration: Oct 23 2002 → Oct 26 2002 |
Keywords
- Cardiovascular model
- Orthostatic stress
- Postural change
- Sheep
ASJC Scopus subject areas
- Signal Processing
- Biomedical Engineering
- Computer Vision and Pattern Recognition
- Health Informatics
