TY - JOUR
T1 - A common 8q24 variant and the risk of colon cancer
T2 - A population-based case-control study
AU - Li, Li
AU - Plummer, Sarah J.
AU - Thompson, Cheryl L.
AU - Merkulova, Alona
AU - Acheson, Louise S.
AU - Tucker, Thomas C.
AU - Casey, Graham
PY - 2008/2/1
Y1 - 2008/2/1
N2 - Three recent studies identified common variants on 8q24 that confer modestly increased susceptibility to colorectal cancer. Here, we replicate the association in a population-based case-control study of colon cancer, including 561 cases and 721 unrelated controls. The rs6983267 marker was significantly associated with colon cancer risk. Compared with those homozygous for the T allele, the heterozygous and homozygous carriers for the G allele had an age-adjusted odds ratio of 1.39 (95% confidence interval, 1.03-1.88) and 1.68 (95% confidence interval, 1.21-2.33), respectively. An additive model showed strong evidence for a gene-dose response relationship (Ptrend = 0.0022). The association remained statistically significant when restricted to Caucasians only (527 cases and 679 controls; Ptrend = 0.0056). Further adjustment for other known risk factors did not alter the results. Stratified analysis revealed no evidence for effect modification by family history of colorectal cancer, age, or gender. These data replicate the association identified from recent studies, providing additional evidence supporting the rs6983267 genetic polymorphism as a marker predisposing to colon cancer.
AB - Three recent studies identified common variants on 8q24 that confer modestly increased susceptibility to colorectal cancer. Here, we replicate the association in a population-based case-control study of colon cancer, including 561 cases and 721 unrelated controls. The rs6983267 marker was significantly associated with colon cancer risk. Compared with those homozygous for the T allele, the heterozygous and homozygous carriers for the G allele had an age-adjusted odds ratio of 1.39 (95% confidence interval, 1.03-1.88) and 1.68 (95% confidence interval, 1.21-2.33), respectively. An additive model showed strong evidence for a gene-dose response relationship (Ptrend = 0.0022). The association remained statistically significant when restricted to Caucasians only (527 cases and 679 controls; Ptrend = 0.0056). Further adjustment for other known risk factors did not alter the results. Stratified analysis revealed no evidence for effect modification by family history of colorectal cancer, age, or gender. These data replicate the association identified from recent studies, providing additional evidence supporting the rs6983267 genetic polymorphism as a marker predisposing to colon cancer.
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U2 - 10.1158/1055-9965.EPI-07-0713
DO - 10.1158/1055-9965.EPI-07-0713
M3 - Article
C2 - 18268117
AN - SCOPUS:39449118229
SN - 1055-9965
VL - 17
SP - 339
EP - 342
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 2
ER -