A comprehensive review on biological properties of citrinin

José Williams Gomes de Oliveira Filho; Muhammad Torequl Islam; Eunus S. Ali; Shaikh Jamal Uddin; Jose Victor de Oliveira Santos; Marcus Vinícius Oliveira Barros de Alencar; Antonio Luiz Gomes Júnior; Márcia Fernanda Correia Jardim Paz; Maria dos Remédios Mendes de Brito; João Marcelo de Castro e Sousa; Subrata Shaw; Maria das Graças Freire de Medeiros; Sandra Maria Mendes de Moura Dantas; Hercília Maria Lins Rolim; Paulo Michel Pinheiro Ferreira; Mohammad Amjad Kamal; Magdalena D. Pieczynska; Niranjan Das; Vijai K. Gupta; Andrei Mocan; Teresinha de Jesus Aguiar dos Santos Andrade; Brahma Nand Singh; Siddhartha K. Mishra; Atanas G. Atanasov; Ana Amélia de Carvalho Melo-Cavalcante

doi:10.1016/j.fct.2017.10.002

A comprehensive review on biological properties of citrinin

José Williams Gomes de Oliveira Filho, Muhammad Torequl Islam, Eunus S. Ali, Shaikh Jamal Uddin, Jose Victor de Oliveira Santos, Marcus Vinícius Oliveira Barros de Alencar, Antonio Luiz Gomes Júnior, Márcia Fernanda Correia Jardim Paz, Maria dos Remédios Mendes de Brito, João Marcelo de Castro e Sousa, Subrata Shaw, Maria das Graças Freire de Medeiros, Sandra Maria Mendes de Moura Dantas, Hercília Maria Lins Rolim, Paulo Michel Pinheiro Ferreira, Mohammad Amjad Kamal, Magdalena D. Pieczynska, Niranjan Das, Vijai K. Gupta, Andrei MocanTeresinha de Jesus Aguiar dos Santos Andrade, Brahma Nand Singh, Siddhartha K. Mishra, Atanas G. Atanasov, Ana Amélia de Carvalho Melo-Cavalcante

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

Citrinin (CIT) is a mycotoxin which causes contamination in the food and is associated with different toxic effects. A web search on CIT has been conducted covering the timespan since 1946. The accumulated data indicate that CIT is produced by several fungal strains belonging to Penicillium, Aspergillus and Monascus genera, and is usually found together with another nephrotoxic mycotoxin, ochratoxin A. Although, it is evident that CIT exposure can exert toxic effects on the heart, liver, kidney, as well as reproductive system, the mechanism of CIT-induced toxicity remains largely elusive. It is still controversial what are the genotoxic and mutagenic effects of CIT. Until now, its toxic effect has been linked to the CIT-mediated oxidative stress and mitochondrial dysfunction in biological systems. However, the toxicity strongly depends on its concentration, route, frequency and time of exposure, as well as from the used test systems. Besides the toxic effects, CIT is also reported to possess a broad spectrum of bioactivities, including antibacterial, antifungal, and potential anticancer and neuro-protective effects in vitro. This systematic review presents the current state of CIT research with emphasis on its bioactivity profile.

Original language	English
Pages (from-to)	130-141
Number of pages	12
Journal	Food and Chemical Toxicology
Volume	110
DOIs	https://doi.org/10.1016/j.fct.2017.10.002
State	Published - Dec 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Ltd

Funding

AGA acknowledges the support by the Austrian Science Fund project P25971-B23 , and by the Polish KNOW (Leading National Research Centre) Scientific Consortium “Healthy Animal—Safe Food” decision of Ministry of Science and Higher Education No. 05-1/KNOW2/2015 . VKG would like to acknowledge funding from EU 7th Framework Programme for research, technological development and demonstration activities under grant agreement No. 621364 (TUTIC-Green).

Funders	Funder number
TUTIC-Green
Seventh Framework Programme	621364
Seventh Framework Programme
Austrian Science Fund/FWF	P25971-B23
Austrian Science Fund/FWF
Ministerstwo Nauki i Szkolnictwa Wyższego	05-1/KNOW2/2015
Ministerstwo Nauki i Szkolnictwa Wyższego

Keywords

Anticancer
Antimicrobial
Citrinin
Genotoxicity
Mycotoxins
Toxicity

ASJC Scopus subject areas

Food Science
Toxicology

Access to Document

10.1016/j.fct.2017.10.002

Cite this

de Oliveira Filho, J. W. G., Islam, M. T., Ali, E. S., Uddin, S. J., Santos, J. V. D. O., de Alencar, M. V. O. B., Júnior, A. L. G., Paz, M. F. C. J., de Brito, M. D. R. M., e Sousa, J. M. D. C., Shaw, S., de Medeiros, M. D. G. F., Dantas, S. M. M. D. M., Rolim, H. M. L., Ferreira, P. M. P., Kamal, M. A., Pieczynska, M. D., Das, N., Gupta, V. K., ... Melo-Cavalcante, A. A. D. C. (2017). A comprehensive review on biological properties of citrinin. Food and Chemical Toxicology, 110, 130-141. https://doi.org/10.1016/j.fct.2017.10.002

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title = "A comprehensive review on biological properties of citrinin",

abstract = "Citrinin (CIT) is a mycotoxin which causes contamination in the food and is associated with different toxic effects. A web search on CIT has been conducted covering the timespan since 1946. The accumulated data indicate that CIT is produced by several fungal strains belonging to Penicillium, Aspergillus and Monascus genera, and is usually found together with another nephrotoxic mycotoxin, ochratoxin A. Although, it is evident that CIT exposure can exert toxic effects on the heart, liver, kidney, as well as reproductive system, the mechanism of CIT-induced toxicity remains largely elusive. It is still controversial what are the genotoxic and mutagenic effects of CIT. Until now, its toxic effect has been linked to the CIT-mediated oxidative stress and mitochondrial dysfunction in biological systems. However, the toxicity strongly depends on its concentration, route, frequency and time of exposure, as well as from the used test systems. Besides the toxic effects, CIT is also reported to possess a broad spectrum of bioactivities, including antibacterial, antifungal, and potential anticancer and neuro-protective effects in vitro. This systematic review presents the current state of CIT research with emphasis on its bioactivity profile.",

keywords = "Anticancer, Antimicrobial, Citrinin, Genotoxicity, Mycotoxins, Toxicity",

author = "{de Oliveira Filho}, {Jos{\'e} Williams Gomes} and Islam, {Muhammad Torequl} and Ali, {Eunus S.} and Uddin, {Shaikh Jamal} and Santos, {Jose Victor de Oliveira} and {de Alencar}, {Marcus Vin{\'i}cius Oliveira Barros} and J{\'u}nior, {Antonio Luiz Gomes} and Paz, {M{\'a}rcia Fernanda Correia Jardim} and {de Brito}, {Maria dos Rem{\'e}dios Mendes} and {e Sousa}, {Jo{\~a}o Marcelo de Castro} and Subrata Shaw and {de Medeiros}, {Maria das Gra{\c c}as Freire} and Dantas, {Sandra Maria Mendes de Moura} and Rolim, {Herc{\'i}lia Maria Lins} and Ferreira, {Paulo Michel Pinheiro} and Kamal, {Mohammad Amjad} and Pieczynska, {Magdalena D.} and Niranjan Das and Gupta, {Vijai K.} and Andrei Mocan and {dos Santos Andrade}, {Teresinha de Jesus Aguiar} and Singh, {Brahma Nand} and Mishra, {Siddhartha K.} and Atanasov, {Atanas G.} and Melo-Cavalcante, {Ana Am{\'e}lia de Carvalho}",

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year = "2017",

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doi = "10.1016/j.fct.2017.10.002",

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de Oliveira Filho, JWG, Islam, MT, Ali, ES, Uddin, SJ, Santos, JVDO, de Alencar, MVOB, Júnior, ALG, Paz, MFCJ, de Brito, MDRM, e Sousa, JMDC, Shaw, S, de Medeiros, MDGF, Dantas, SMMDM, Rolim, HML, Ferreira, PMP, Kamal, MA, Pieczynska, MD, Das, N, Gupta, VK, Mocan, A, dos Santos Andrade, TDJA, Singh, BN, Mishra, SK, Atanasov, AG & Melo-Cavalcante, AADC 2017, 'A comprehensive review on biological properties of citrinin', Food and Chemical Toxicology, vol. 110, pp. 130-141. https://doi.org/10.1016/j.fct.2017.10.002

TY - JOUR

T1 - A comprehensive review on biological properties of citrinin

AU - de Oliveira Filho, José Williams Gomes

AU - Islam, Muhammad Torequl

AU - Ali, Eunus S.

AU - Uddin, Shaikh Jamal

AU - Santos, Jose Victor de Oliveira

AU - de Alencar, Marcus Vinícius Oliveira Barros

AU - Júnior, Antonio Luiz Gomes

AU - Paz, Márcia Fernanda Correia Jardim

AU - de Brito, Maria dos Remédios Mendes

AU - e Sousa, João Marcelo de Castro

AU - Shaw, Subrata

AU - de Medeiros, Maria das Graças Freire

AU - Dantas, Sandra Maria Mendes de Moura

AU - Rolim, Hercília Maria Lins

AU - Ferreira, Paulo Michel Pinheiro

AU - Kamal, Mohammad Amjad

AU - Pieczynska, Magdalena D.

AU - Das, Niranjan

AU - Gupta, Vijai K.

AU - Mocan, Andrei

AU - dos Santos Andrade, Teresinha de Jesus Aguiar

AU - Singh, Brahma Nand

AU - Mishra, Siddhartha K.

AU - Atanasov, Atanas G.

AU - Melo-Cavalcante, Ana Amélia de Carvalho

PY - 2017/12

Y1 - 2017/12

N2 - Citrinin (CIT) is a mycotoxin which causes contamination in the food and is associated with different toxic effects. A web search on CIT has been conducted covering the timespan since 1946. The accumulated data indicate that CIT is produced by several fungal strains belonging to Penicillium, Aspergillus and Monascus genera, and is usually found together with another nephrotoxic mycotoxin, ochratoxin A. Although, it is evident that CIT exposure can exert toxic effects on the heart, liver, kidney, as well as reproductive system, the mechanism of CIT-induced toxicity remains largely elusive. It is still controversial what are the genotoxic and mutagenic effects of CIT. Until now, its toxic effect has been linked to the CIT-mediated oxidative stress and mitochondrial dysfunction in biological systems. However, the toxicity strongly depends on its concentration, route, frequency and time of exposure, as well as from the used test systems. Besides the toxic effects, CIT is also reported to possess a broad spectrum of bioactivities, including antibacterial, antifungal, and potential anticancer and neuro-protective effects in vitro. This systematic review presents the current state of CIT research with emphasis on its bioactivity profile.

AB - Citrinin (CIT) is a mycotoxin which causes contamination in the food and is associated with different toxic effects. A web search on CIT has been conducted covering the timespan since 1946. The accumulated data indicate that CIT is produced by several fungal strains belonging to Penicillium, Aspergillus and Monascus genera, and is usually found together with another nephrotoxic mycotoxin, ochratoxin A. Although, it is evident that CIT exposure can exert toxic effects on the heart, liver, kidney, as well as reproductive system, the mechanism of CIT-induced toxicity remains largely elusive. It is still controversial what are the genotoxic and mutagenic effects of CIT. Until now, its toxic effect has been linked to the CIT-mediated oxidative stress and mitochondrial dysfunction in biological systems. However, the toxicity strongly depends on its concentration, route, frequency and time of exposure, as well as from the used test systems. Besides the toxic effects, CIT is also reported to possess a broad spectrum of bioactivities, including antibacterial, antifungal, and potential anticancer and neuro-protective effects in vitro. This systematic review presents the current state of CIT research with emphasis on its bioactivity profile.

KW - Anticancer

KW - Antimicrobial

KW - Citrinin

KW - Genotoxicity

KW - Mycotoxins

KW - Toxicity

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A comprehensive review on biological properties of citrinin

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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