A concise synthesis of (S)-(+)-1-(4-{2-[bis-(4-fluorophenyl)methoxy]-ethyl} piperazin-1-yl)-2-phenylpropan-2-ol dimaleate

Thomas Prisinzano; Ling Wei Hsin; John E. Folk; Judith L. Flippen-Anderson; Clifford George; Arthur E. Jacobson; Kenner C. Rice

doi:10.1016/j.tetasy.2003.05.001

A concise synthesis of (S)-(+)-1-(4-{2-[bis-(4-fluorophenyl)methoxy]-ethyl} piperazin-1-yl)-2-phenylpropan-2-ol dimaleate

Thomas Prisinzano, Ling Wei Hsin, John E. Folk, Judith L. Flippen-Anderson, Clifford George, Arthur E. Jacobson, Kenner C. Rice

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

(S)-(+)-1-(4-{2-[Bis-(4-fluorophenyl)methoxy]-ethyl}piperazin-1-yl) -2-phenylpropan-2-ol dimaleate was prepared in several steps from (S)-(+)-atrolactic acid by a process permitting synthesis of multigram quantities. With the information provided by asymmetric synthesis, the X-ray crystal structure was solved.

Original language	English
Pages (from-to)	3285-3289
Number of pages	5
Journal	Tetrahedron Asymmetry
Volume	14
Issue number	21
DOIs	https://doi.org/10.1016/j.tetasy.2003.05.001
State	Published - Oct 31 2003

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ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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title = "A concise synthesis of (S)-(+)-1-(4-{2-[bis-(4-fluorophenyl)methoxy]-ethyl} piperazin-1-yl)-2-phenylpropan-2-ol dimaleate",

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T1 - A concise synthesis of (S)-(+)-1-(4-{2-[bis-(4-fluorophenyl)methoxy]-ethyl} piperazin-1-yl)-2-phenylpropan-2-ol dimaleate

AU - Prisinzano, Thomas

AU - Hsin, Ling Wei

AU - Folk, John E.

AU - Flippen-Anderson, Judith L.

AU - George, Clifford

AU - Jacobson, Arthur E.

AU - Rice, Kenner C.

PY - 2003/10/31

Y1 - 2003/10/31

N2 - (S)-(+)-1-(4-{2-[Bis-(4-fluorophenyl)methoxy]-ethyl}piperazin-1-yl) -2-phenylpropan-2-ol dimaleate was prepared in several steps from (S)-(+)-atrolactic acid by a process permitting synthesis of multigram quantities. With the information provided by asymmetric synthesis, the X-ray crystal structure was solved.

AB - (S)-(+)-1-(4-{2-[Bis-(4-fluorophenyl)methoxy]-ethyl}piperazin-1-yl) -2-phenylpropan-2-ol dimaleate was prepared in several steps from (S)-(+)-atrolactic acid by a process permitting synthesis of multigram quantities. With the information provided by asymmetric synthesis, the X-ray crystal structure was solved.

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ER -

A concise synthesis of (S)-(+)-1-(4-{2-[bis-(4-fluorophenyl)methoxy]-ethyl} piperazin-1-yl)-2-phenylpropan-2-ol dimaleate

Abstract

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