A concise synthesis of (S)-(+)-1-(4-{2-[bis-(4-fluorophenyl)methoxy]-ethyl} piperazin-1-yl)-2-phenylpropan-2-ol dimaleate

Thomas Prisinzano, Ling Wei Hsin, John E. Folk, Judith L. Flippen-Anderson, Clifford George, Arthur E. Jacobson, Kenner C. Rice

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


(S)-(+)-1-(4-{2-[Bis-(4-fluorophenyl)methoxy]-ethyl}piperazin-1-yl) -2-phenylpropan-2-ol dimaleate was prepared in several steps from (S)-(+)-atrolactic acid by a process permitting synthesis of multigram quantities. With the information provided by asymmetric synthesis, the X-ray crystal structure was solved.

Original languageEnglish
Pages (from-to)3285-3289
Number of pages5
JournalTetrahedron Asymmetry
Issue number21
StatePublished - Oct 31 2003

Bibliographical note

Copyright 2021 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


Dive into the research topics of 'A concise synthesis of (S)-(+)-1-(4-{2-[bis-(4-fluorophenyl)methoxy]-ethyl} piperazin-1-yl)-2-phenylpropan-2-ol dimaleate'. Together they form a unique fingerprint.

Cite this