A convenient procedure for parallel ester hydrolysis

Marc O. Anderson, Jamie Moser, John Sherrill, R. Kiplin Guy

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


The treatment of alkyl esters with barium hydroxide octahydrate in methanol followed by protonation with anhydrous hydrogen chloride affords carboxylic acids. The procedure does not require aqueous workup and is particularly suitable for parallel synthesis applications.

Original languageEnglish
Pages (from-to)2391-2393
Number of pages3
Issue number13
StatePublished - Nov 3 2004


  • 9-Chloroacridine
  • Barium hydroxide octahydrate
  • Deprotection
  • Ester hydrolysis
  • Parallel synthesis

ASJC Scopus subject areas

  • Organic Chemistry


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