Abstract
The treatment of alkyl esters with barium hydroxide octahydrate in methanol followed by protonation with anhydrous hydrogen chloride affords carboxylic acids. The procedure does not require aqueous workup and is particularly suitable for parallel synthesis applications.
Original language | English |
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Pages (from-to) | 2391-2393 |
Number of pages | 3 |
Journal | Synlett |
Issue number | 13 |
DOIs | |
State | Published - Nov 3 2004 |
Keywords
- 9-Chloroacridine
- Barium hydroxide octahydrate
- Deprotection
- Ester hydrolysis
- Parallel synthesis
ASJC Scopus subject areas
- Organic Chemistry