Abstract
Tyrosine kinases are key regulators of breast cancer cell survival and proliferation. Ten years ago, we conducted a screen for protein kinases expressed in primary human breast tumors and cultured cancer cells. Here, we review the progress from the last ten years in understanding the functions of these kinases with a focus on breast cancer. Three themes emerge: (1) tyrosine kinases regulate proliferation through the MAP Kinase pathway, (2) tyrosine kinases regulate cellular survival through the PI3 Kinase-Akt pathway, and (3) the cell cycle is regulated through a complex series of serine-threonine kinases. Our improved understanding of these signaling cascades has led to novel strategies for therapeutic intervention in breast cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 39-49 |
| Number of pages | 11 |
| Journal | Surgical Oncology |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 2003 |
Bibliographical note
Funding Information:R.J.C. is a scholar of the Building Interdisciplinary Research Careers in Women's Health (BIRCWH) program through the NIH (K12HD001441). This work was funded in part by the University of North Carolina University Research Council. W.G.C. is funded by NIH grants CA69510 and CA83895.
Keywords
- Apoptosis
- Cancer
- Review
- Signaling
- Tyrosine kinase
ASJC Scopus subject areas
- Surgery
- Oncology
