A decade of tyrosine kinases: From gene discovery to therapeutics

Rolf J. Craven, Harry Lightfoot, William G. Cance

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Tyrosine kinases are key regulators of breast cancer cell survival and proliferation. Ten years ago, we conducted a screen for protein kinases expressed in primary human breast tumors and cultured cancer cells. Here, we review the progress from the last ten years in understanding the functions of these kinases with a focus on breast cancer. Three themes emerge: (1) tyrosine kinases regulate proliferation through the MAP Kinase pathway, (2) tyrosine kinases regulate cellular survival through the PI3 Kinase-Akt pathway, and (3) the cell cycle is regulated through a complex series of serine-threonine kinases. Our improved understanding of these signaling cascades has led to novel strategies for therapeutic intervention in breast cancer.

Original languageEnglish
Pages (from-to)39-49
Number of pages11
JournalSurgical Oncology
Volume12
Issue number1
DOIs
StatePublished - Jul 2003

Bibliographical note

Funding Information:
R.J.C. is a scholar of the Building Interdisciplinary Research Careers in Women's Health (BIRCWH) program through the NIH (K12HD001441). This work was funded in part by the University of North Carolina University Research Council. W.G.C. is funded by NIH grants CA69510 and CA83895.

Keywords

  • Apoptosis
  • Cancer
  • Review
  • Signaling
  • Tyrosine kinase

ASJC Scopus subject areas

  • Surgery
  • Oncology

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