TY - GEN
T1 - A decision-theoretic model of selection modulated intra-host antigenic variation for multi-strain pathogens
AU - Chattopadhyay, Ishanu
AU - Mohinta, Sonia
AU - Ray, Asok
PY - 2010
Y1 - 2010
N2 - A decision-theoretic approach to modeling the response of multi-strain pathogens to humoral defense is investigated in this paper. The reported theory of language-measure theoretic optimal control is used to compute the optimal response of the invading pathogen. The model is validated by comparison of simulation results with in-vivo observations and contrasted with prominent existing modeling approaches.
AB - A decision-theoretic approach to modeling the response of multi-strain pathogens to humoral defense is investigated in this paper. The reported theory of language-measure theoretic optimal control is used to compute the optimal response of the invading pathogen. The model is validated by comparison of simulation results with in-vivo observations and contrasted with prominent existing modeling approaches.
KW - Antigenic drift
KW - Discrete event systems
KW - Finite markov chains
KW - Language measure
KW - Multi-strain pathogens
UR - http://www.scopus.com/inward/record.url?scp=77957840512&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957840512&partnerID=8YFLogxK
U2 - 10.1109/acc.2010.5530990
DO - 10.1109/acc.2010.5530990
M3 - Conference contribution
AN - SCOPUS:77957840512
SN - 9781424474264
T3 - Proceedings of the 2010 American Control Conference, ACC 2010
SP - 454
EP - 459
BT - Proceedings of the 2010 American Control Conference, ACC 2010
ER -