Abstract
Salvinorin A is a novel hallucinogen isolated from the widely available leaves of Salvia divinorum. Based on its mechanism of action, salvinorin A has shown potential as a stimulant abuse therapeutic. However, there are no methods for the detection of salvinorin A or its metabolites in biological fluids. In order to begin developing salvinorin A as a potential therapeutic, an understanding of its metabolism is needed. Here, a straightforward synthesis of a deuterium labeled analog of salvinorin A and its utility as an internal standard for the detection of salvinorin A and its metabolites in biological fluids by LC-MS is described.
Original language | English |
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Pages (from-to) | 5099-5102 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 14 |
Issue number | 20 |
DOIs | |
State | Published - Oct 18 2004 |
Bibliographical note
Funding Information:The authors thank the College of Pharmacy and the Biological Sciences Funding Program of the University of Iowa for financial support.
Funding
The authors thank the College of Pharmacy and the Biological Sciences Funding Program of the University of Iowa for financial support.
Funders | Funder number |
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Iowa Environmental Mesonet at Iowa State University |
Keywords
- Deuterium
- Hallucinogen
- Salvia divinorum
- Salvinorin A
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry