A Facile One-Pot Synthesis of Symmetrical and Unsymmetrical Acetaldehyde Acetals from Primary Alcohols

Rodney Kiplin Guy; Richard Anthony DiPietro

doi:10.1080/00397919208019270

A Facile One-Pot Synthesis of Symmetrical and Unsymmetrical Acetaldehyde Acetals from Primary Alcohols

Rodney Kiplin Guy, Richard Anthony DiPietro

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Initial formation of a vinyl ether 2 by treatment of a primary alcohol 1 with ethyl vinyl ether in the presence of mercury (II) acetate followed by treatment with the same or a different alcohol in the presence of p-toluenesulfonic acid affords the symmetrical and unsymmetrical acetaldehyde acetals 3 in good overall yield. The method is easily scaled up and represents a significant improvement over currently available procedures.

Original language	English
Pages (from-to)	687-692
Number of pages	6
Journal	Synthetic Communications
Volume	22
Issue number	5
DOIs	https://doi.org/10.1080/00397919208019270
State	Published - Mar 1 1992

ASJC Scopus subject areas

Organic Chemistry

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10.1080/00397919208019270

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title = "A Facile One-Pot Synthesis of Symmetrical and Unsymmetrical Acetaldehyde Acetals from Primary Alcohols",

abstract = "Initial formation of a vinyl ether 2 by treatment of a primary alcohol 1 with ethyl vinyl ether in the presence of mercury (II) acetate followed by treatment with the same or a different alcohol in the presence of p-toluenesulfonic acid affords the symmetrical and unsymmetrical acetaldehyde acetals 3 in good overall yield. The method is easily scaled up and represents a significant improvement over currently available procedures.",

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N2 - Initial formation of a vinyl ether 2 by treatment of a primary alcohol 1 with ethyl vinyl ether in the presence of mercury (II) acetate followed by treatment with the same or a different alcohol in the presence of p-toluenesulfonic acid affords the symmetrical and unsymmetrical acetaldehyde acetals 3 in good overall yield. The method is easily scaled up and represents a significant improvement over currently available procedures.

AB - Initial formation of a vinyl ether 2 by treatment of a primary alcohol 1 with ethyl vinyl ether in the presence of mercury (II) acetate followed by treatment with the same or a different alcohol in the presence of p-toluenesulfonic acid affords the symmetrical and unsymmetrical acetaldehyde acetals 3 in good overall yield. The method is easily scaled up and represents a significant improvement over currently available procedures.

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A Facile One-Pot Synthesis of Symmetrical and Unsymmetrical Acetaldehyde Acetals from Primary Alcohols

Abstract

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