A Free Radical Primer

Prachi Gupta, Andrew Lakes, Thomas Dziubla

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

29 Scopus citations


Free radicals, reactive oxygen species, and reactive nitrogen species are the result of the oxidation-reduction reactions that are constantly taking place around us, such as combustion, photosynthesis, rusting, and cellular metabolism. In this chapter, the mechanisms of free radical production and their importance in natural chemical processes is discussed. Parallels are made between different systems as a means of underlining the similarities and fundamental relationships these reactions have in nature. Following the redox potential principles, the concept is extended to the cellular metabolic pathways, where different reactions in the cellular matrix result in the generation and consumption of free radicals or reactive intermediates, which define the redox sate of a cell. With this background, a deeper understanding on the relationship between free radicals, oxidative stress and biomaterials can be obtained.

Original languageEnglish
Title of host publicationOxidative Stress and Biomaterials
Number of pages33
ISBN (Electronic)9780128032701
StatePublished - Jun 1 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc. All rights reserved.


  • Cellular enzymes
  • Fenton Chemistry
  • Free radical
  • Haber-Weiss Reaction
  • Redox potential
  • Thiol chemistry

ASJC Scopus subject areas

  • General Engineering
  • General Materials Science


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