A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium

Rongwen Xi; Jennifer R. McGregor; Douglas A. Harrison

doi:10.1016/S1534-5807(02)00412-4

A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium

Rongwen Xi, Jennifer R. McGregor, Douglas A. Harrison

Research output: Contribution to journal › Article › peer-review

164 Scopus citations

Abstract

The Drosophila egg develops through closely coordinated activities of associated germline and somatic cells. An essential aspect of egg development is the differentiation of the somatic follicle cells into several distinct subpopulations with specific functions. Here we demonstrate that the graded activity of the Janus kinase (JAK) pathway, stimulated by the Unpaired ligand, patterns the anterior-posterior axis of the follicular epithelium. Different levels of JAK activity instruct adoption of distinct anterior cell fates. Further, the coordinated activities of the JAK/STAT and epidermal growth factor receptor (EGFR) pathways are required to specify the posterior terminal cell fate. We propose that Upd secreted from the polar cells may act as a morphogen to stimulate A/P-derived follicular fates through JAK pathway activation.

Original language	English
Pages (from-to)	167-177
Number of pages	11
Journal	Developmental Cell
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/S1534-5807(02)00412-4
State	Published - Feb 1 2003

Bibliographical note

Funding Information:
We gratefully acknowledge Drs. J. Duffy, H. Ruohola-Baker, T. Schupbach, D. St. Johnston, M. Zeidler, and S. Hou and the Bloomington Stock Center for sharing fly strains or other reagents. We also thank Drs. T. Schupbach, D. Montell, D. St. Johnston, H. Ruohola-Baker, J. Lengyel, and K. Johansen for helpful discussions and/or comments on the manuscript. This work was supported by grants from the National Science Foundation to D.A.H. (IBN-9723944 and -0091535).

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

Access to Document

10.1016/S1534-5807(02)00412-4

Cite this

@article{770b2a1a8c2842a893c1cdf4e099690d,

title = "A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium",

abstract = "The Drosophila egg develops through closely coordinated activities of associated germline and somatic cells. An essential aspect of egg development is the differentiation of the somatic follicle cells into several distinct subpopulations with specific functions. Here we demonstrate that the graded activity of the Janus kinase (JAK) pathway, stimulated by the Unpaired ligand, patterns the anterior-posterior axis of the follicular epithelium. Different levels of JAK activity instruct adoption of distinct anterior cell fates. Further, the coordinated activities of the JAK/STAT and epidermal growth factor receptor (EGFR) pathways are required to specify the posterior terminal cell fate. We propose that Upd secreted from the polar cells may act as a morphogen to stimulate A/P-derived follicular fates through JAK pathway activation.",

author = "Rongwen Xi and McGregor, {Jennifer R.} and Harrison, {Douglas A.}",

note = "Funding Information: We gratefully acknowledge Drs. J. Duffy, H. Ruohola-Baker, T. Schupbach, D. St. Johnston, M. Zeidler, and S. Hou and the Bloomington Stock Center for sharing fly strains or other reagents. We also thank Drs. T. Schupbach, D. Montell, D. St. Johnston, H. Ruohola-Baker, J. Lengyel, and K. Johansen for helpful discussions and/or comments on the manuscript. This work was supported by grants from the National Science Foundation to D.A.H. (IBN-9723944 and -0091535).",

year = "2003",

month = feb,

day = "1",

doi = "10.1016/S1534-5807(02)00412-4",

language = "English",

volume = "4",

pages = "167--177",

number = "2",

}

TY - JOUR

T1 - A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium

AU - Xi, Rongwen

AU - McGregor, Jennifer R.

AU - Harrison, Douglas A.

N1 - Funding Information: We gratefully acknowledge Drs. J. Duffy, H. Ruohola-Baker, T. Schupbach, D. St. Johnston, M. Zeidler, and S. Hou and the Bloomington Stock Center for sharing fly strains or other reagents. We also thank Drs. T. Schupbach, D. Montell, D. St. Johnston, H. Ruohola-Baker, J. Lengyel, and K. Johansen for helpful discussions and/or comments on the manuscript. This work was supported by grants from the National Science Foundation to D.A.H. (IBN-9723944 and -0091535).

PY - 2003/2/1

Y1 - 2003/2/1

N2 - The Drosophila egg develops through closely coordinated activities of associated germline and somatic cells. An essential aspect of egg development is the differentiation of the somatic follicle cells into several distinct subpopulations with specific functions. Here we demonstrate that the graded activity of the Janus kinase (JAK) pathway, stimulated by the Unpaired ligand, patterns the anterior-posterior axis of the follicular epithelium. Different levels of JAK activity instruct adoption of distinct anterior cell fates. Further, the coordinated activities of the JAK/STAT and epidermal growth factor receptor (EGFR) pathways are required to specify the posterior terminal cell fate. We propose that Upd secreted from the polar cells may act as a morphogen to stimulate A/P-derived follicular fates through JAK pathway activation.

AB - The Drosophila egg develops through closely coordinated activities of associated germline and somatic cells. An essential aspect of egg development is the differentiation of the somatic follicle cells into several distinct subpopulations with specific functions. Here we demonstrate that the graded activity of the Janus kinase (JAK) pathway, stimulated by the Unpaired ligand, patterns the anterior-posterior axis of the follicular epithelium. Different levels of JAK activity instruct adoption of distinct anterior cell fates. Further, the coordinated activities of the JAK/STAT and epidermal growth factor receptor (EGFR) pathways are required to specify the posterior terminal cell fate. We propose that Upd secreted from the polar cells may act as a morphogen to stimulate A/P-derived follicular fates through JAK pathway activation.

UR - http://www.scopus.com/inward/record.url?scp=0037320198&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037320198&partnerID=8YFLogxK

U2 - 10.1016/S1534-5807(02)00412-4

DO - 10.1016/S1534-5807(02)00412-4

M3 - Article

C2 - 12586061

AN - SCOPUS:0037320198

SN - 1534-5807

VL - 4

SP - 167

EP - 177

JO - Developmental Cell

JF - Developmental Cell

IS - 2

ER -

A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this