TY - JOUR
T1 - A guide to murine coagulation factor structure, function, assays, and genetic alterations
AU - Emeis, J. J.
AU - Jirouskova, M.
AU - Muchitsch, E. M.
AU - Shet, A. S.
AU - Smyth, S. S.
AU - Johnson, Gerard J.
PY - 2007/4
Y1 - 2007/4
N2 - Murine blood coagulation factors and function are quite similar to those of humans. Because of this similarity and the adaptability of mice to genetic manipulation, murine coagulation factors and inhibitors have been extensively studied. These studies have provided significant insights into human hemostasis. They have also provided useful experimental models for evaluation of the pathophysiology and treatment of thrombosis. This review contains recommendations for obtaining, processing and assaying mouse blood hemostatic components, and it summarizes the extensive literature on murine coagulation factor structure and function, assays and genetic alteration. It is intended to be a convenient reference source for investigators of hemostasis and thrombosis.
AB - Murine blood coagulation factors and function are quite similar to those of humans. Because of this similarity and the adaptability of mice to genetic manipulation, murine coagulation factors and inhibitors have been extensively studied. These studies have provided significant insights into human hemostasis. They have also provided useful experimental models for evaluation of the pathophysiology and treatment of thrombosis. This review contains recommendations for obtaining, processing and assaying mouse blood hemostatic components, and it summarizes the extensive literature on murine coagulation factor structure and function, assays and genetic alteration. It is intended to be a convenient reference source for investigators of hemostasis and thrombosis.
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U2 - 10.1111/j.1538-7836.2007.02408.x
DO - 10.1111/j.1538-7836.2007.02408.x
M3 - Review article
C2 - 17403201
AN - SCOPUS:34147177201
SN - 1538-7933
VL - 5
SP - 670
EP - 679
JO - Journal of Thrombosis and Haemostasis
JF - Journal of Thrombosis and Haemostasis
IS - 4
ER -