A hybrid method for fast Monte Carlo simulation of diffuse reflectance from a multi-layered tissue model with tumor-like heterogeneities

Caigang Zhu, Quan Liu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

We present a hybrid method to speed up the Monte Carlo simulation of diffuse reflectance from a multi-layered tissue model with finite-size tumor-like heterogeneities. The proposed method consists of two steps. In the first step, a set of photon trajectory information generated from a baseline Monte Carlo simulation is utilized to scale the exit weight and exit distance of survival photons for the multi-layered tissue model by using a multiple scaling method. In the second step, another set of photon trajectory information including the locations of all collision events from the baseline simulation and the scaling result obtained from the first step are employed by the perturbation Monte Carlo method to estimate diffuse reflectance from the multi-layered tissue model with tumor-like heterogeneities. Our method is demonstrated to be able to shorten simulation time by several orders of magnitude. Moreover, this hybrid method works for a larger range of probe configurations and tumor models compared to the scaling method or the perturbation method alone.

Original languageEnglish
Title of host publicationOptical Interactions with Tissue and Cells XXIII
DOIs
StatePublished - 2012
EventOptical Interactions with Tissue and Cells XXIII - San Francisco, CA, United States
Duration: Jan 23 2012Jan 25 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8221
ISSN (Print)1605-7422

Conference

ConferenceOptical Interactions with Tissue and Cells XXIII
Country/TerritoryUnited States
CitySan Francisco, CA
Period1/23/121/25/12

Keywords

  • Perturbation Monte Carlo
  • Scaling method
  • diffuse reflectance
  • epithelial cancer
  • tumor-like heterogeneity

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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