TY - GEN
T1 - A less biased analysis of metalloproteins' coordination geometries
AU - Yao, Sen
AU - Flight, Robert M.
AU - Rouchka, Eric C.
AU - Moseley, Hunter N.B.
PY - 2015/9/9
Y1 - 2015/9/9
N2 - Metalloproteins are essential to all domains of life. The structure of the metalloproteins, especially the metal ion's coordination geometry (CG), needs to be carefully studied, because it provides a strong bridge between metal-binding protein sequences and their functions. Our previous study has shown that new CGs can be classified in zinc metalloproteins via a less biased analysis, and these new CGs also demonstrated distinct functional propensity. Applying the methodology to all metalloproteins will greatly help us in better understanding metalloproteins' structure and their contribution to the protein functions.
AB - Metalloproteins are essential to all domains of life. The structure of the metalloproteins, especially the metal ion's coordination geometry (CG), needs to be carefully studied, because it provides a strong bridge between metal-binding protein sequences and their functions. Our previous study has shown that new CGs can be classified in zinc metalloproteins via a less biased analysis, and these new CGs also demonstrated distinct functional propensity. Applying the methodology to all metalloproteins will greatly help us in better understanding metalloproteins' structure and their contribution to the protein functions.
KW - Coordination geometry (CG)
KW - Metalloproteins
KW - Structural conformation
UR - http://www.scopus.com/inward/record.url?scp=84963542589&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84963542589&partnerID=8YFLogxK
U2 - 10.1145/2808719.2811424
DO - 10.1145/2808719.2811424
M3 - Conference contribution
AN - SCOPUS:84963542589
T3 - BCB 2015 - 6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics
SP - 493
EP - 494
BT - BCB 2015 - 6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics
T2 - 6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, BCB 2015
Y2 - 9 September 2015 through 12 September 2015
ER -