A less biased analysis of metalloproteins' coordination geometries

Sen Yao; Robert M. Flight; Eric C. Rouchka; Hunter N.B. Moseley

doi:10.1145/2808719.2811424

A less biased analysis of metalloproteins' coordination geometries

Sen Yao, Robert M. Flight, Eric C. Rouchka, Hunter N.B. Moseley

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Metalloproteins are essential to all domains of life. The structure of the metalloproteins, especially the metal ion's coordination geometry (CG), needs to be carefully studied, because it provides a strong bridge between metal-binding protein sequences and their functions. Our previous study has shown that new CGs can be classified in zinc metalloproteins via a less biased analysis, and these new CGs also demonstrated distinct functional propensity. Applying the methodology to all metalloproteins will greatly help us in better understanding metalloproteins' structure and their contribution to the protein functions.

Original language	English
Title of host publication	BCB 2015 - 6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics
Pages	493-494
Number of pages	2
ISBN (Electronic)	9781450338530
DOIs	https://doi.org/10.1145/2808719.2811424
State	Published - Sep 9 2015
Event	6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, BCB 2015 - Atlanta, United States Duration: Sep 9 2015 → Sep 12 2015

Publication series

Name	BCB 2015 - 6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics

Conference

Conference	6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, BCB 2015
Country/Territory	United States
City	Atlanta
Period	9/9/15 → 9/12/15

Bibliographical note

Publisher Copyright:
Copyright is held by the author/owner(s).

Keywords

Coordination geometry (CG)
Metalloproteins
Structural conformation

ASJC Scopus subject areas

Software
Health Informatics
Computer Science Applications
Biomedical Engineering

Access to Document

10.1145/2808719.2811424

Cite this

Yao, S., Flight, R. M., Rouchka, E. C., & Moseley, H. N. B. (2015). A less biased analysis of metalloproteins' coordination geometries. In BCB 2015 - 6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics (pp. 493-494). (BCB 2015 - 6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics). https://doi.org/10.1145/2808719.2811424

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keywords = "Coordination geometry (CG), Metalloproteins, Structural conformation",

author = "Sen Yao and Flight, {Robert M.} and Rouchka, {Eric C.} and Moseley, {Hunter N.B.}",

note = "Publisher Copyright: Copyright is held by the author/owner(s).; 6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, BCB 2015 ; Conference date: 09-09-2015 Through 12-09-2015",

year = "2015",

month = sep,

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doi = "10.1145/2808719.2811424",

language = "English",

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Yao, S, Flight, RM, Rouchka, EC & Moseley, HNB 2015, A less biased analysis of metalloproteins' coordination geometries. in BCB 2015 - 6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics. BCB 2015 - 6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, pp. 493-494, 6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, BCB 2015, Atlanta, United States, 9/9/15. https://doi.org/10.1145/2808719.2811424

A less biased analysis of metalloproteins' coordination geometries. / Yao, Sen; Flight, Robert M.; Rouchka, Eric C. et al.
BCB 2015 - 6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics. 2015. p. 493-494 (BCB 2015 - 6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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N2 - Metalloproteins are essential to all domains of life. The structure of the metalloproteins, especially the metal ion's coordination geometry (CG), needs to be carefully studied, because it provides a strong bridge between metal-binding protein sequences and their functions. Our previous study has shown that new CGs can be classified in zinc metalloproteins via a less biased analysis, and these new CGs also demonstrated distinct functional propensity. Applying the methodology to all metalloproteins will greatly help us in better understanding metalloproteins' structure and their contribution to the protein functions.

AB - Metalloproteins are essential to all domains of life. The structure of the metalloproteins, especially the metal ion's coordination geometry (CG), needs to be carefully studied, because it provides a strong bridge between metal-binding protein sequences and their functions. Our previous study has shown that new CGs can be classified in zinc metalloproteins via a less biased analysis, and these new CGs also demonstrated distinct functional propensity. Applying the methodology to all metalloproteins will greatly help us in better understanding metalloproteins' structure and their contribution to the protein functions.

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A less biased analysis of metalloproteins' coordination geometries

Abstract

Publication series

Conference

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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