The stability and variability of older adults’ late-differentiated peripheral blood T and natural killer (NK) cells over time remains incompletely quantified or understood. We examined the variability and change over time in T and NK cell subsets in a longitudinal sample of older adults; the effects of sex, cytomegalovirus (CMV) serostatus, and chronic disease severity on immune levels and trajectories; and interdependencies among T and NK cell subsets. Older adults (N = 149, age 64–94 years, 42% male) provided blood every 6 months for 2.5 years (up to 5 waves) to evaluate late-differentiated CD8 T cells (CD28− CD57+) and CD56 dim NK cells (CD57+, NKG2C+, FcɛRIγ−). In multilevel models, most of the variance in immune subsets reflected stable differences between people. However, CD56 dim NK cell subsets (CD57+ and FcɛRIγ−) also increased with age, whereas T cell subsets did not. Independent of age, all subsets examined were higher in CMV-positive older adults. Men had higher levels of CD56 dim CD57+ than women. Chronic disease was not associated with any immune subset investigated. T and NK cell subsets correlated within each cell type, but interdependencies differed by CMV serostatus. Our results suggest the accumulation of these stable cell populations may be driven less by chronological aging, even less by chronic disease severity, and more by CMV, which may differentially skew T and NK cell differentiation.
|Number of pages||9|
|State||Published - Jul 1 2019|
Bibliographical noteFunding Information:
The UK Flow Cytometry & Cell Sorting core facility is supported in part by the Office of the Vice President for Research, the Markey Cancer Center and an NCI Center Core Support Grant (P30 CA177558) to the University of Kentucky Markey Cancer Center.
This work was supported by the National Institute on Aging ( K99-AG056635 [RGR], R01-AG026307 [SCS], K02-AG033629 [SCS], P30-AG028383 ).
© 2019 Elsevier Inc.
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology