A low temperature cofired ceramic microfluidic calorimeter for ELISA biosensing

Benjamin Brummel, Bradley Berron, Richard E. Eitel

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The expense and difficulty of current biomarker detection methods is driving the design of microfluidic detection platforms. A ceramic microfluidic biosensor has been developed for conducting enzyme-linked immunosorbent assays (ELISA) using a novel polymerization amplified thermal detection (PATD) scheme. Prototype testing has yielded several results that support the viability of this device. It was seen that LTCC is an effective and durable substrate for the temperature sensor. Noise testing with our prototype revealed that our temperature sensors can detect changes as small as 0.01 K. Additional temperature testing showed that the thermistor behavior matches the expected thermistor beta equation. Finally, it was shown that polymerization reaction induction time is inversely proportional to glucose oxidase (GOx) initiator concentration. These preliminary results provide a foundation for future work developing the sensor into a protein detection device with cancer prognosis applications.

Original languageEnglish
Title of host publication9th IMAPS/ACerS International Conference and Exhibition on Ceramic Interconnect and Ceramic Microsystems Technologies, CICMT 2013
Pages168-172
Number of pages5
StatePublished - 2013
Event9th IMAPS/ACerS International Conference and Exhibition on Ceramic Interconnect and Ceramic Microsystems Technologies, CICMT 2013 - Orlando, FL, United States
Duration: Apr 23 2013Apr 25 2013

Publication series

Name9th IMAPS/ACerS International Conference and Exhibition on Ceramic Interconnect and Ceramic Microsystems Technologies, CICMT 2013

Conference

Conference9th IMAPS/ACerS International Conference and Exhibition on Ceramic Interconnect and Ceramic Microsystems Technologies, CICMT 2013
Country/TerritoryUnited States
CityOrlando, FL
Period4/23/134/25/13

ASJC Scopus subject areas

  • Hardware and Architecture
  • Control and Systems Engineering

Fingerprint

Dive into the research topics of 'A low temperature cofired ceramic microfluidic calorimeter for ELISA biosensing'. Together they form a unique fingerprint.

Cite this