TY - GEN
T1 - A mathematical model of ultradian sleep-wake regulation in rodents
AU - Wang, Hao
AU - Yaghouby, Farid
AU - Sunderam, Sridhar
PY - 2016/10/13
Y1 - 2016/10/13
N2 - Rodent models are widely used for the experimental analysis of sleep. While this is motivated by similarities in brain circuitry and electrophysiological rhythms, unlike the circadian sleep-wake cycle in humans, rodent sleep is polyphasic, containing multiple bouts of sleep and wake minutes to hours in duration over the course of a day. Each sleep bout is punctuated by several brief arousals several seconds to minutes long. Physiologically motivated mathematical models replicate the shorter timescale of arousal within sleep, but not the longer one representing prolonged wakefulness. Here, we adapt a previously published 'flip-flop' model of human sleep to capture the ultradian alternation of sleep and wakefulness in mice on the longer timescale. The resulting model reproduces both the mean durations of alternating sleep and wake bouts as well as the circadian trends in their bout durations documented in our experiments on mice.
AB - Rodent models are widely used for the experimental analysis of sleep. While this is motivated by similarities in brain circuitry and electrophysiological rhythms, unlike the circadian sleep-wake cycle in humans, rodent sleep is polyphasic, containing multiple bouts of sleep and wake minutes to hours in duration over the course of a day. Each sleep bout is punctuated by several brief arousals several seconds to minutes long. Physiologically motivated mathematical models replicate the shorter timescale of arousal within sleep, but not the longer one representing prolonged wakefulness. Here, we adapt a previously published 'flip-flop' model of human sleep to capture the ultradian alternation of sleep and wakefulness in mice on the longer timescale. The resulting model reproduces both the mean durations of alternating sleep and wake bouts as well as the circadian trends in their bout durations documented in our experiments on mice.
UR - http://www.scopus.com/inward/record.url?scp=85009126797&partnerID=8YFLogxK
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U2 - 10.1109/EMBC.2016.7591032
DO - 10.1109/EMBC.2016.7591032
M3 - Conference contribution
C2 - 28268648
AN - SCOPUS:85009126797
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 1656
EP - 1659
BT - 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
T2 - 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
Y2 - 16 August 2016 through 20 August 2016
ER -