TY - JOUR
T1 - A matter of life or death (or both)
T2 - Understanding autophagy in cancer
AU - Hait, William N.
AU - Jin, Shengkan
AU - Yang, Jin Ming
PY - 2006/4/1
Y1 - 2006/4/1
N2 - Autophagy is a highly conserved pathway that can be used for survival during nutrient and growth factor deprivation. Under certain circumstances, it seems that autophagy may serve as a pathway to cell death. Already, it is becoming increasingly clear that autophagy is involved in cancer formation, survival, and response to several forms of cancer treatments. A detailed understanding of how this pathway is regulated is now emerging and will allow translation of this information into new approaches to cancer treatment.
AB - Autophagy is a highly conserved pathway that can be used for survival during nutrient and growth factor deprivation. Under certain circumstances, it seems that autophagy may serve as a pathway to cell death. Already, it is becoming increasingly clear that autophagy is involved in cancer formation, survival, and response to several forms of cancer treatments. A detailed understanding of how this pathway is regulated is now emerging and will allow translation of this information into new approaches to cancer treatment.
UR - http://www.scopus.com/inward/record.url?scp=33646271855&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646271855&partnerID=8YFLogxK
U2 - 10.1158/1078-0432.CCR-06-0011
DO - 10.1158/1078-0432.CCR-06-0011
M3 - Review article
C2 - 16609004
AN - SCOPUS:33646271855
SN - 1078-0432
VL - 12
SP - 1961
EP - 1965
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 7 I
ER -
