Abstract
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10-11) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10-10). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10 -8). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10-7), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.
Original language | English |
---|---|
Pages (from-to) | 690-696 |
Number of pages | 7 |
Journal | Nature Genetics |
Volume | 45 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2013 |
ASJC Scopus subject areas
- Genetics
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In: Nature Genetics, Vol. 45, No. 6, 06.2013, p. 690-696.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
AU - Monda, Keri L.
AU - Chen, Gary K.
AU - Taylor, Kira C.
AU - Palmer, Cameron
AU - Edwards, Todd L.
AU - Lange, Leslie A.
AU - Ng, Maggie C.Y.
AU - Adeyemo, Adebowale A.
AU - Allison, Matthew A.
AU - Bielak, Lawrence F.
AU - Chen, Guanjie
AU - Graff, Mariaelisa
AU - Irvin, Marguerite R.
AU - Rhie, Suhn K.
AU - Li, Guo
AU - Liu, Yongmei
AU - Liu, Youfang
AU - Lu, Yingchang
AU - Nalls, Michael A.
AU - Sun, Yan V.
AU - Wojczynski, Mary K.
AU - Yanek, Lisa R.
AU - Aldrich, Melinda C.
AU - Ademola, Adeyinka
AU - Amos, Christopher I.
AU - Bandera, Elisa V.
AU - Bock, Cathryn H.
AU - Britton, Angela
AU - Broeckel, Ulrich
AU - Cai, Quiyin
AU - Caporaso, Neil E.
AU - Carlson, Chris S.
AU - Carpten, John
AU - Casey, Graham
AU - Chen, Wei Min
AU - Chen, Fang
AU - Chen, Yii Der I.
AU - Chiang, Charleston W.K.
AU - Coetzee, Gerhard A.
AU - Demerath, Ellen
AU - Deming-Halverson, Sandra L.
AU - Driver, Ryan W.
AU - Dubbert, Patricia
AU - Feitosa, Mary F.
AU - Feng, Ye
AU - Freedman, Barry I.
AU - Gillanders, Elizabeth M.
AU - Gottesman, Omri
AU - Guo, Xiuqing
AU - Haritunians, Talin
AU - Harris, Tamara
AU - Harris, Curtis C.
AU - Hennis, Anselm J.M.
AU - Hernandez, Dena G.
AU - McNeill, Lorna H.
AU - Howard, Timothy D.
AU - Howard, Barbara V.
AU - Howard, Virginia J.
AU - Johnson, Karen C.
AU - Kang, Sun J.
AU - Keating, Brendan J.
AU - Kolb, Suzanne
AU - Kuller, Lewis H.
AU - Kutlar, Abdullah
AU - Langefeld, Carl D.
AU - Lettre, Guillaume
AU - Lohman, Kurt
AU - Lotay, Vaneet
AU - Lyon, Helen
AU - Manson, Joann E.
AU - Maixner, William
AU - Meng, Yan A.
AU - Monroe, Kristine R.
AU - Morhason-Bello, Imran
AU - Murphy, Adam B.
AU - Mychaleckyj, Josyf C.
AU - Nadukuru, Rajiv
AU - Nathanson, Katherine L.
AU - Nayak, Uma
AU - N'Diaye, Amidou
AU - Nemesure, Barbara
AU - Wu, Suh Yuh
AU - Leske, M. Cristina
AU - Neslund-Dudas, Christine
AU - Neuhouser, Marian
AU - Nyante, Sarah
AU - Ochs-Balcom, Heather
AU - Ogunniyi, Adesola
AU - Ogundiran, Temidayo O.
AU - Ojengbede, Oladosu
AU - Olopade, Olufunmilayo I.
AU - Palmer, Julie R.
AU - Ruiz-Narvaez, Edward A.
AU - Palmer, Nicholette D.
AU - Press, Michael F.
AU - Rampersaud, Evandine
AU - Rasmussen-Torvik, Laura J.
AU - Rodriguez-Gil, Jorge L.
AU - Salako, Babatunde
AU - Schadt, Eric E.
AU - Schwartz, Ann G.
AU - Shriner, Daniel A.
AU - Siscovick, David
AU - Smith, Shad B.
AU - Wassertheil-Smoller, Sylvia
AU - Speliotes, Elizabeth K.
AU - Spitz, Margaret R.
AU - Sucheston, Lara
AU - Taylor, Herman
AU - Tayo, Bamidele O.
AU - Tucker, Margaret A.
AU - Van Den Berg, David J.
AU - Edwards, Digna R.Velez
AU - Wang, Zhaoming
AU - Wiencke, John K.
AU - Winkler, Thomas W.
AU - Witte, John S.
AU - Wrensch, Margaret
AU - Wu, Xifeng
AU - Yang, James J.
AU - Levin, Albert M.
AU - Young, Taylor R.
AU - Zakai, Neil A.
AU - Cushman, Mary
AU - Zanetti, Krista A.
AU - Zhao, Jing Hua
AU - Zhao, Wei
AU - Zheng, Yonglan
AU - Zhou, Jie
AU - Ziegler, Regina G.
AU - Zmuda, Joseph M.
AU - Fernandes, Jyotika K.
AU - Gilkeson, Gary S.
AU - Kamen, Diane L.
AU - Hunt, Kelly J.
AU - Spruill, Ida J.
AU - Ambrosone, Christine B.
AU - Ambs, Stefan
AU - Arnett, Donna K.
AU - Atwood, Larry
AU - Becker, Diane M.
AU - Berndt, Sonja I.
AU - Bernstein, Leslie
AU - Blot, William J.
AU - Borecki, Ingrid B.
AU - Bottinger, Erwin P.
AU - Bowden, Donald W.
AU - Burke, Gregory
AU - Chanock, Stephen J.
AU - Cooper, Richard S.
AU - Ding, Jingzhong
AU - Duggan, David
AU - Evans, Michele K.
AU - Fox, Caroline
AU - Garvey, W. Timothy
AU - Bradfield, Jonathan P.
AU - Hakonarson, Hakon
AU - Grant, Struan F.A.
AU - Hsing, Ann
AU - Chu, Lisa
AU - Hu, Jennifer J.
AU - Huo, Dezheng
AU - Ingles, Sue A.
AU - John, Esther M.
AU - Jordan, Joanne M.
AU - Kabagambe, Edmond K.
AU - Kardia, Sharon L.R.
AU - Kittles, Rick A.
AU - Goodman, Phyllis J.
AU - Klein, Eric A.
AU - Kolonel, Laurence N.
AU - Le Marchand, Loic
AU - Liu, Simin
AU - McKnight, Barbara
AU - Millikan, Robert C.
AU - Mosley, Thomas H.
AU - Padhukasahasram, Badri
AU - Williams, L. Keoki
AU - Patel, Sanjay R.
AU - Peters, Ulrike
AU - Pettaway, Curtis A.
AU - Peyser, Patricia A.
AU - Psaty, Bruce M.
AU - Redline, Susan
AU - Rotimi, Charles N.
AU - Rybicki, Benjamin A.
AU - Sale, Michèle M.
AU - Schreiner, Pamela J.
AU - Signorello, Lisa B.
AU - Singleton, Andrew B.
AU - Stanford, Janet L.
AU - Strom, Sara S.
AU - Thun, Michael J.
AU - Vitolins, Mara
AU - Zheng, Wei
AU - Moore, Jason H.
AU - Williams, Scott M.
AU - Ketkar, Shamika
AU - Zhu, Xiaofeng
AU - Zonderman, Alan B.
AU - Kooperberg, Charles
AU - Papanicolaou, George J.
AU - Henderson, Brian E.
AU - Reiner, Alex P.
AU - Hirschhorn, Joel N.
AU - Loos, Ruth J.F.
AU - North, Kari E.
AU - Haiman, Christopher A.
PY - 2013/6
Y1 - 2013/6
N2 - Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10-11) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10-10). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10 -8). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10-7), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.
AB - Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10-11) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10-10). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10 -8). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10-7), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.
UR - http://www.scopus.com/inward/record.url?scp=84878720938&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878720938&partnerID=8YFLogxK
U2 - 10.1038/ng.2608
DO - 10.1038/ng.2608
M3 - Article
C2 - 23583978
AN - SCOPUS:84878720938
SN - 1061-4036
VL - 45
SP - 690
EP - 696
JO - Nature Genetics
JF - Nature Genetics
IS - 6
ER -