A microfabricated preconcentration device for breath analysis

Mingxiao Li; Souvik Biswas; Michael H. Nantz; Richard M. Higashi; Xiao An Fu

doi:10.1016/j.snb.2012.07.034

A microfabricated preconcentration device for breath analysis

Mingxiao Li, Souvik Biswas, Michael H. Nantz, Richard M. Higashi, Xiao An Fu

Toxicology and Cancer Biology

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Breath analysis promises to be a noninvasive method for diagnosis of lung cancer in its early stages. Certain ketones and aldehydes in exhaled breath have been identified as indicators of lung cancer. We report a preconcentration device or preconcentrator with thousands of micropillars fabricated from a silicon wafer that have been engineered to selectively trap trace gaseous ketones and aldehydes in exhaled breath. The micropillar surfaces were functionalized with a quaternary ammonium aminooxy salt, 2-(aminooxy)ethyl-N,N,N-trimethylammonium iodide (ATM), for capturing trace carbonyl compounds flowing through the preconcentrator by means of an oximation reaction. The unreacted ATM and reacted ATM adducts were eluted out of the preconcentrator with methanol and were directly analyzed by Fourier transform-ion cyclotron resonance mass spectrometry (FTICR-MS). The preconcentration results indicate that the capture percentages of acetone depend on the molar ratio of ATM/acetone. The analysis of exhaled breath demonstrates that the preconcentrator is suitable for quantitative analysis of ketones and aldehydes in exhaled breath.

Original language	English
Pages (from-to)	130-136
Number of pages	7
Journal	Sensors and Actuators, B: Chemical
Volume	180
DOIs	https://doi.org/10.1016/j.snb.2012.07.034
State	Published - Apr 1 2013

Bibliographical note

Funding Information:
We gratefully acknowledge the University of Louisville for financial support of this research through the Clinical and Translational Science Pilot Grant Program (CTSPGP-20035). The authors thank the support of the CREAM Mass Spectrometry Facility initially funded by NSF/EPSCoR grant # EPS-0447479 ), Profs. T. Fan and A.N. Lane, PIs. The authors also wish to thank Profs. T. Fan, A.N. Lane, and M. Bousamra, M.D. for discussions.

Publisher Copyright:
© 2012 Elsevier B.V.

Keywords

Breath analysis
FTICR-MS
Fabrication
Ketones and aldehyde
Preconcentrator

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.snb.2012.07.034

Cite this

@article{940e0f3eb3314f7eaf181efecde2353e,

title = "A microfabricated preconcentration device for breath analysis",

abstract = "Breath analysis promises to be a noninvasive method for diagnosis of lung cancer in its early stages. Certain ketones and aldehydes in exhaled breath have been identified as indicators of lung cancer. We report a preconcentration device or preconcentrator with thousands of micropillars fabricated from a silicon wafer that have been engineered to selectively trap trace gaseous ketones and aldehydes in exhaled breath. The micropillar surfaces were functionalized with a quaternary ammonium aminooxy salt, 2-(aminooxy)ethyl-N,N,N-trimethylammonium iodide (ATM), for capturing trace carbonyl compounds flowing through the preconcentrator by means of an oximation reaction. The unreacted ATM and reacted ATM adducts were eluted out of the preconcentrator with methanol and were directly analyzed by Fourier transform-ion cyclotron resonance mass spectrometry (FTICR-MS). The preconcentration results indicate that the capture percentages of acetone depend on the molar ratio of ATM/acetone. The analysis of exhaled breath demonstrates that the preconcentrator is suitable for quantitative analysis of ketones and aldehydes in exhaled breath.",

keywords = "Breath analysis, FTICR-MS, Fabrication, Ketones and aldehyde, Preconcentrator",

author = "Mingxiao Li and Souvik Biswas and Nantz, {Michael H.} and Higashi, {Richard M.} and Fu, {Xiao An}",

year = "2013",

month = apr,

day = "1",

doi = "10.1016/j.snb.2012.07.034",

language = "English",

volume = "180",

pages = "130--136",

}

TY - JOUR

T1 - A microfabricated preconcentration device for breath analysis

AU - Li, Mingxiao

AU - Biswas, Souvik

AU - Nantz, Michael H.

AU - Higashi, Richard M.

AU - Fu, Xiao An

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Breath analysis promises to be a noninvasive method for diagnosis of lung cancer in its early stages. Certain ketones and aldehydes in exhaled breath have been identified as indicators of lung cancer. We report a preconcentration device or preconcentrator with thousands of micropillars fabricated from a silicon wafer that have been engineered to selectively trap trace gaseous ketones and aldehydes in exhaled breath. The micropillar surfaces were functionalized with a quaternary ammonium aminooxy salt, 2-(aminooxy)ethyl-N,N,N-trimethylammonium iodide (ATM), for capturing trace carbonyl compounds flowing through the preconcentrator by means of an oximation reaction. The unreacted ATM and reacted ATM adducts were eluted out of the preconcentrator with methanol and were directly analyzed by Fourier transform-ion cyclotron resonance mass spectrometry (FTICR-MS). The preconcentration results indicate that the capture percentages of acetone depend on the molar ratio of ATM/acetone. The analysis of exhaled breath demonstrates that the preconcentrator is suitable for quantitative analysis of ketones and aldehydes in exhaled breath.

AB - Breath analysis promises to be a noninvasive method for diagnosis of lung cancer in its early stages. Certain ketones and aldehydes in exhaled breath have been identified as indicators of lung cancer. We report a preconcentration device or preconcentrator with thousands of micropillars fabricated from a silicon wafer that have been engineered to selectively trap trace gaseous ketones and aldehydes in exhaled breath. The micropillar surfaces were functionalized with a quaternary ammonium aminooxy salt, 2-(aminooxy)ethyl-N,N,N-trimethylammonium iodide (ATM), for capturing trace carbonyl compounds flowing through the preconcentrator by means of an oximation reaction. The unreacted ATM and reacted ATM adducts were eluted out of the preconcentrator with methanol and were directly analyzed by Fourier transform-ion cyclotron resonance mass spectrometry (FTICR-MS). The preconcentration results indicate that the capture percentages of acetone depend on the molar ratio of ATM/acetone. The analysis of exhaled breath demonstrates that the preconcentrator is suitable for quantitative analysis of ketones and aldehydes in exhaled breath.

KW - Breath analysis

KW - FTICR-MS

KW - Fabrication

KW - Ketones and aldehyde

KW - Preconcentrator

UR - http://www.scopus.com/inward/record.url?scp=84866676148&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866676148&partnerID=8YFLogxK

U2 - 10.1016/j.snb.2012.07.034

DO - 10.1016/j.snb.2012.07.034

M3 - Article

AN - SCOPUS:84866676148

SN - 0925-4005

VL - 180

SP - 130

EP - 136

JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

ER -

A microfabricated preconcentration device for breath analysis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this