A model of the pacemaking neuron of the respiratory central pattern generator

Behrang Amini; Akhil Bidani; Joseph B. Zwischenberger; John W. Clark

doi:10.1109/TNSRE.2005.847379

A model of the pacemaking neuron of the respiratory central pattern generator

Behrang Amini, Akhil Bidani, Joseph B. Zwischenberger, John W. Clark

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We have developed a model of the mammalian respiratory central pattern generator (rCPG) to mimic the salient characteristics of its constituent medullary neurons. This model is designed as a network of Hodgkin-Huxley-type medullary neurons driven by a pacemaking neuron from the pre-Bötzinger complex. Here, we present the results of our model of this pacemaking neuron, based on available voltage clamp data. Implications for the behavior of the rCPG are discussed.

Original language	English
Pages (from-to)	120-124
Number of pages	5
Journal	IEEE Transactions on Neural Systems and Rehabilitation Engineering
Volume	13
Issue number	2
DOIs	https://doi.org/10.1109/TNSRE.2005.847379
State	Published - Jun 2005

Keywords

Biological system modeling
Hodgkin-Huxley models
Neural networks
Respiratory system

ASJC Scopus subject areas

Internal Medicine
General Neuroscience
Biomedical Engineering
Rehabilitation

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10.1109/TNSRE.2005.847379

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abstract = "We have developed a model of the mammalian respiratory central pattern generator (rCPG) to mimic the salient characteristics of its constituent medullary neurons. This model is designed as a network of Hodgkin-Huxley-type medullary neurons driven by a pacemaking neuron from the pre-B{\"o}tzinger complex. Here, we present the results of our model of this pacemaking neuron, based on available voltage clamp data. Implications for the behavior of the rCPG are discussed.",

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AU - Clark, John W.

PY - 2005/6

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AB - We have developed a model of the mammalian respiratory central pattern generator (rCPG) to mimic the salient characteristics of its constituent medullary neurons. This model is designed as a network of Hodgkin-Huxley-type medullary neurons driven by a pacemaking neuron from the pre-Bötzinger complex. Here, we present the results of our model of this pacemaking neuron, based on available voltage clamp data. Implications for the behavior of the rCPG are discussed.

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KW - Hodgkin-Huxley models

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KW - Respiratory system

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JO - IEEE Transactions on Neural Systems and Rehabilitation Engineering

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A model of the pacemaking neuron of the respiratory central pattern generator

Abstract

Keywords

ASJC Scopus subject areas

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