TY - JOUR
T1 - A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood
AU - Kurniansyah, Nuzulul
AU - Goodman, Matthew O.
AU - Kelly, Tanika N.
AU - Elfassy, Tali
AU - Wiggins, Kerri L.
AU - Bis, Joshua C.
AU - Guo, Xiuqing
AU - Palmas, Walter
AU - Taylor, Kent D.
AU - Lin, Henry J.
AU - Haessler, Jeffrey
AU - Gao, Yan
AU - Shimbo, Daichi
AU - Smith, Jennifer A.
AU - Yu, Bing
AU - Feofanova, Elena V.
AU - Smit, Roelof A.J.
AU - Wang, Zhe
AU - Hwang, Shih Jen
AU - Liu, Simin
AU - Wassertheil-Smoller, Sylvia
AU - Manson, Jo Ann E.
AU - Lloyd-Jones, Donald M.
AU - Rich, Stephen S.
AU - Loos, Ruth J.F.
AU - Redline, Susan
AU - Correa, Adolfo
AU - Kooperberg, Charles
AU - Fornage, Myriam
AU - Kaplan, Robert C.
AU - Psaty, Bruce M.
AU - Rotter, Jerome I.
AU - Arnett, Donna K.
AU - Morrison, Alanna C.
AU - Franceschini, Nora
AU - Levy, Daniel
AU - Bis, Joshua C.
AU - Guo, Xiuqing
AU - Taylor, Kent D.
AU - Lin, Henry J.
AU - Haessler, Jeffrey
AU - Gao, Yan
AU - Smith, Jennifer A.
AU - Wassertheil-Smoller, Sylvia
AU - Manson, Jo Ann E.
AU - Rich, Stephen S.
AU - Correa, Adolfo
AU - Kooperberg, Charles
AU - Kaplan, Robert C.
AU - Rotter, Jerome I.
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12/1
Y1 - 2022/12/1
N2 - In a multi-stage analysis of 52,436 individuals aged 17-90 across diverse cohorts and biobanks, we train, test, and evaluate a polygenic risk score (PRS) for hypertension risk and progression. The PRS is trained using genome-wide association studies (GWAS) for systolic, diastolic blood pressure, and hypertension, respectively. For each trait, PRS is selected by optimizing the coefficient of variation (CV) across estimated effect sizes from multiple potential PRS using the same GWAS, after which the 3 trait-specific PRSs are combined via an unweighted sum called “PRSsum”, forming the HTN-PRS. The HTN-PRS is associated with both prevalent and incident hypertension at 4-6 years of follow up. This association is further confirmed in age-stratified analysis. In an independent biobank of 40,201 individuals, the HTN-PRS is confirmed to be predictive of increased risk for coronary artery disease, ischemic stroke, type 2 diabetes, and chronic kidney disease.
AB - In a multi-stage analysis of 52,436 individuals aged 17-90 across diverse cohorts and biobanks, we train, test, and evaluate a polygenic risk score (PRS) for hypertension risk and progression. The PRS is trained using genome-wide association studies (GWAS) for systolic, diastolic blood pressure, and hypertension, respectively. For each trait, PRS is selected by optimizing the coefficient of variation (CV) across estimated effect sizes from multiple potential PRS using the same GWAS, after which the 3 trait-specific PRSs are combined via an unweighted sum called “PRSsum”, forming the HTN-PRS. The HTN-PRS is associated with both prevalent and incident hypertension at 4-6 years of follow up. This association is further confirmed in age-stratified analysis. In an independent biobank of 40,201 individuals, the HTN-PRS is confirmed to be predictive of increased risk for coronary artery disease, ischemic stroke, type 2 diabetes, and chronic kidney disease.
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U2 - 10.1038/s41467-022-31080-2
DO - 10.1038/s41467-022-31080-2
M3 - Article
C2 - 35729114
AN - SCOPUS:85132292699
SN - 2041-1723
VL - 13
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 3549
ER -
