A multicenter study of total pancreatectomy with islet autotransplantation (TPIAT): POST (Prospective Observational Study of TPIAT)

doi:10.1016/j.pan.2018.02.001

A multicenter study of total pancreatectomy with islet autotransplantation (TPIAT): POST (Prospective Observational Study of TPIAT)

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Background/objectives: Total pancreatectomy with islet autotransplantation (TPIAT) is considered for managing chronic pancreatitis in selected patients when medical and endoscopic interventions have not provided adequate relief from debilitating pain. Although more centers are performing TPIAT, we lack large, multi-center studies to guide decisions about selecting candidates for and timing of TPIAT. Methods: Multiple centers across the United States (9 to date) performing TPIAT are prospectively enrolling patients undergoing TPIAT for chronic pancreatitis into the Prospective Observational Study of TPIAT (POST), a NIDDK funded study with a goal of accruing 450 TPIAT recipients. Baseline data include participant phenotype, pancreatitis history, and medical/psychological comorbidities from medical records, participant interview, and participant self-report (Medical Outcomes Survey Short Form-12, EQ-5D, andPROMIS inventories for pain interference, depression, and anxiety). Outcome measures are collected to at least 1 year after TPIAT, including the same participant questionnaires, visual analog pain scale, pain interference scores, opioid requirements, insulin requirements, islet graft function, and hemoglobin A1c. Health resource utilization data are collected for a cost-effectiveness analysis. Biorepository specimens including urine, serum/plasma, genetic material (saliva and blood), and pancreas tissue are collected for future study. Conclusions: This ongoing multicenter research study will enroll and follow TPIAT recipients, aiming to evaluate patient selection and timing for TPIAT to optimize pain relief, quality of life, and diabetes outcomes, and to measure the procedure's cost-effectiveness. A biorepository is also established for future ancillary studies.

Original language	English
Pages (from-to)	286-290
Number of pages	5
Journal	Pancreatology
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/j.pan.2018.02.001
State	Published - Apr 2018

Bibliographical note

Publisher Copyright:
© 2018 IAP and EPC

Funding

The study is funded by the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK, R01- DK109124 , PI M. Bellin). Research reported in this publication was additionally supported by the National Cancer Institute and NIDDK under award number U01DK108327 (DC). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors have no conflicts of interest to disclose relevant to this manuscript. The authors would like to acknowledge the efforts of the supporting team members Helen Voelker (University of Minnesota, DCC database management), Yi Yang (University of Minnesota, Biostatistics), Joshua J. Wilhelm (University of Minnesota, islet lab), Dr, Kenneth Washburn (The Ohio State University, Surgery), and Dr, Amer Rajab (The Ohio State University, Surgery and Islet Isolation), and the following study coordinators: Peggy Ptacek (University of Minnesota), Jayne Pederson (University of Minnesota), Anne Elizabeth Farrow (Baylor), Jovana Valdez (Baylor), Misty Troutt (Cincinnati Children's Hospital), Amanda Schreibeis (Cincinnati Children's Hospital), Jessica Chevalier (Dartmouth Hitchcock), Jessica Hiscoe (Dartmouth Hitchcock), Mahya Faghih (John Hopkins), Sheila Fedorek (University of Pittsburgh), Lindsay Basto (University of Chicago), Mortadha Abd (Medical University of South Carolina), Caitlin Schaffner (Medical University of South Carolina), Casey McClurkin (The Ohio State University), Brianna Conley (The Ohio State University), Alejandra Cervantes (The Ohio State University), Jill Buss (The Ohio State University), Emily Bowns (The Ohio State University). The study is funded by the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK, R01- DK109124, PI M. Bellin). Research reported in this publication was additionally supported by the National Cancer Institute and NIDDK under award number U01DK108327 (DC). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors have no conflicts of interest to disclose relevant to this manuscript. The authors would like to acknowledge the efforts of the supporting team members Helen Voelker (University of Minnesota, DCC database management), Yi Yang (University of Minnesota, Biostatistics), Joshua J. Wilhelm (University of Minnesota, islet lab), Dr, Kenneth Washburn (The Ohio State University, Surgery), and Dr, Amer Rajab (The Ohio State University, Surgery and Islet Isolation), and the following study coordinators: Peggy Ptacek (University of Minnesota), Jayne Pederson (University of Minnesota), Anne Elizabeth Farrow (Baylor), Jovana Valdez (Baylor), Misty Troutt (Cincinnati Children's Hospital), Amanda Schreibeis (Cincinnati Children's Hospital), Jessica Chevalier (Dartmouth Hitchcock), Jessica Hiscoe (Dartmouth Hitchcock), Mahya Faghih (John Hopkins), Sheila Fedorek (University of Pittsburgh), Lindsay Basto (University of Chicago), Mortadha Abd (Medical University of South Carolina), Caitlin Schaffner (Medical University of South Carolina), Casey McClurkin (The Ohio State University), Brianna Conley (The Ohio State University), Alejandra Cervantes (The Ohio State University), Jill Buss (The Ohio State University), Emily Bowns (The Ohio State University).

Funders	Funder number
Amanda Schreibeis
Brianna Conley
Casey McClurkin
Jessica Chevalier
Kenneth Washburn
Mahya Faghih
Misty Troutt
National Institutes of Health (NIH)
National Childhood Cancer Registry – National Cancer Institute
National Institute of Diabetes and Digestive and Kidney Diseases	U01DK108327, R01- DK109124
Ohio State University
Cincinnati Children's Hospital Medical Center
The University of Chicago
Minnesota State University-Mankato
University of Pittsburgh Medical Center, Children's Hospital of Pittsburgh

Keywords

Diabetes
Islet
Pain
Pancreatitis
Total pancreatectomy

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Hepatology
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.pan.2018.02.001

Cite this

@article{0432fe4d16724652ab57467a852e8d89,

title = "A multicenter study of total pancreatectomy with islet autotransplantation (TPIAT): POST (Prospective Observational Study of TPIAT)",

abstract = "Background/objectives: Total pancreatectomy with islet autotransplantation (TPIAT) is considered for managing chronic pancreatitis in selected patients when medical and endoscopic interventions have not provided adequate relief from debilitating pain. Although more centers are performing TPIAT, we lack large, multi-center studies to guide decisions about selecting candidates for and timing of TPIAT. Methods: Multiple centers across the United States (9 to date) performing TPIAT are prospectively enrolling patients undergoing TPIAT for chronic pancreatitis into the Prospective Observational Study of TPIAT (POST), a NIDDK funded study with a goal of accruing 450 TPIAT recipients. Baseline data include participant phenotype, pancreatitis history, and medical/psychological comorbidities from medical records, participant interview, and participant self-report (Medical Outcomes Survey Short Form-12, EQ-5D, andPROMIS inventories for pain interference, depression, and anxiety). Outcome measures are collected to at least 1 year after TPIAT, including the same participant questionnaires, visual analog pain scale, pain interference scores, opioid requirements, insulin requirements, islet graft function, and hemoglobin A1c. Health resource utilization data are collected for a cost-effectiveness analysis. Biorepository specimens including urine, serum/plasma, genetic material (saliva and blood), and pancreas tissue are collected for future study. Conclusions: This ongoing multicenter research study will enroll and follow TPIAT recipients, aiming to evaluate patient selection and timing for TPIAT to optimize pain relief, quality of life, and diabetes outcomes, and to measure the procedure's cost-effectiveness. A biorepository is also established for future ancillary studies.",

keywords = "Diabetes, Islet, Pain, Pancreatitis, Total pancreatectomy",

author = "Bellin, {Melena D.} and Maisam Abu-El-Haija and Katherine Morgan and David Adams and Beilman, {Gregory J.} and Srinath Chinnakotla and Conwell, {Darwin L.} and Dunn, {Ty B.} and Freeman, {Martin L.} and Timothy Gardner and Kirchner, {Varvara A.} and Lara, {Luis F.} and Leslie Long-Simpson and Nathan, {Jaimie D.} and Bashoo Naziruddin and Nyman, {John A.} and Pruett, {Timothy L.} and Schwarzenberg, {Sarah J.} and Singh, {Vikesh K.} and Kerrington Smith and Steel, {Jennifer L.} and Martin Wijkstrom and Piotr Witkowski and Hodges, {James S.}",

note = "Publisher Copyright: {\textcopyright} 2018 IAP and EPC",

year = "2018",

month = apr,

doi = "10.1016/j.pan.2018.02.001",

language = "English",

volume = "18",

pages = "286--290",

journal = "Pancreatology",

issn = "1424-3903",

publisher = "Elsevier BV",

number = "3",

}

TY - JOUR

T1 - A multicenter study of total pancreatectomy with islet autotransplantation (TPIAT)

T2 - POST (Prospective Observational Study of TPIAT)

AU - Bellin, Melena D.

AU - Abu-El-Haija, Maisam

AU - Morgan, Katherine

AU - Adams, David

AU - Beilman, Gregory J.

AU - Chinnakotla, Srinath

AU - Conwell, Darwin L.

AU - Dunn, Ty B.

AU - Freeman, Martin L.

AU - Gardner, Timothy

AU - Kirchner, Varvara A.

AU - Lara, Luis F.

AU - Long-Simpson, Leslie

AU - Nathan, Jaimie D.

AU - Naziruddin, Bashoo

AU - Nyman, John A.

AU - Pruett, Timothy L.

AU - Schwarzenberg, Sarah J.

AU - Singh, Vikesh K.

AU - Smith, Kerrington

AU - Steel, Jennifer L.

AU - Wijkstrom, Martin

AU - Witkowski, Piotr

AU - Hodges, James S.

PY - 2018/4

Y1 - 2018/4

N2 - Background/objectives: Total pancreatectomy with islet autotransplantation (TPIAT) is considered for managing chronic pancreatitis in selected patients when medical and endoscopic interventions have not provided adequate relief from debilitating pain. Although more centers are performing TPIAT, we lack large, multi-center studies to guide decisions about selecting candidates for and timing of TPIAT. Methods: Multiple centers across the United States (9 to date) performing TPIAT are prospectively enrolling patients undergoing TPIAT for chronic pancreatitis into the Prospective Observational Study of TPIAT (POST), a NIDDK funded study with a goal of accruing 450 TPIAT recipients. Baseline data include participant phenotype, pancreatitis history, and medical/psychological comorbidities from medical records, participant interview, and participant self-report (Medical Outcomes Survey Short Form-12, EQ-5D, andPROMIS inventories for pain interference, depression, and anxiety). Outcome measures are collected to at least 1 year after TPIAT, including the same participant questionnaires, visual analog pain scale, pain interference scores, opioid requirements, insulin requirements, islet graft function, and hemoglobin A1c. Health resource utilization data are collected for a cost-effectiveness analysis. Biorepository specimens including urine, serum/plasma, genetic material (saliva and blood), and pancreas tissue are collected for future study. Conclusions: This ongoing multicenter research study will enroll and follow TPIAT recipients, aiming to evaluate patient selection and timing for TPIAT to optimize pain relief, quality of life, and diabetes outcomes, and to measure the procedure's cost-effectiveness. A biorepository is also established for future ancillary studies.

AB - Background/objectives: Total pancreatectomy with islet autotransplantation (TPIAT) is considered for managing chronic pancreatitis in selected patients when medical and endoscopic interventions have not provided adequate relief from debilitating pain. Although more centers are performing TPIAT, we lack large, multi-center studies to guide decisions about selecting candidates for and timing of TPIAT. Methods: Multiple centers across the United States (9 to date) performing TPIAT are prospectively enrolling patients undergoing TPIAT for chronic pancreatitis into the Prospective Observational Study of TPIAT (POST), a NIDDK funded study with a goal of accruing 450 TPIAT recipients. Baseline data include participant phenotype, pancreatitis history, and medical/psychological comorbidities from medical records, participant interview, and participant self-report (Medical Outcomes Survey Short Form-12, EQ-5D, andPROMIS inventories for pain interference, depression, and anxiety). Outcome measures are collected to at least 1 year after TPIAT, including the same participant questionnaires, visual analog pain scale, pain interference scores, opioid requirements, insulin requirements, islet graft function, and hemoglobin A1c. Health resource utilization data are collected for a cost-effectiveness analysis. Biorepository specimens including urine, serum/plasma, genetic material (saliva and blood), and pancreas tissue are collected for future study. Conclusions: This ongoing multicenter research study will enroll and follow TPIAT recipients, aiming to evaluate patient selection and timing for TPIAT to optimize pain relief, quality of life, and diabetes outcomes, and to measure the procedure's cost-effectiveness. A biorepository is also established for future ancillary studies.

KW - Diabetes

KW - Islet

KW - Pain

KW - Pancreatitis

KW - Total pancreatectomy

UR - http://www.scopus.com/inward/record.url?scp=85042011342&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042011342&partnerID=8YFLogxK

U2 - 10.1016/j.pan.2018.02.001

DO - 10.1016/j.pan.2018.02.001

M3 - Article

C2 - 29456124

AN - SCOPUS:85042011342

SN - 1424-3903

VL - 18

SP - 286

EP - 290

JO - Pancreatology

JF - Pancreatology

IS - 3

ER -

A multicenter study of total pancreatectomy with islet autotransplantation (TPIAT): POST (Prospective Observational Study of TPIAT)

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this