A murine model of myocardial ischemia–Reperfusion Injury

Zhaobin Xu, Kevin E. McElhanon, Eric X. Beck, Noah Weisleder

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

23 Scopus citations

Abstract

Ligation of the left anterior descending (LAD) coronary artery in the mouse heart is a widely used model to simulate myocardial infarction and ischemia–reperfusion injury. Here we describe a ligation technique routinely performed in our laboratory to induce myocardial infarction that may be used to study ischemia–reperfusion injury in the myocardium. The methods described enhance location of the LAD coronary artery to allow for accurate ligation, thus increasing reproducibility of infarct size and location.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
Pages145-153
Number of pages9
DOIs
StatePublished - 2018

Publication series

NameMethods in Molecular Biology
Volume1717
ISSN (Print)1064-3745

Bibliographical note

Publisher Copyright:
© 2018, Springer Science+Business Media, LLC.

Keywords

  • LAD ligation
  • Left anterior descending coronary artery
  • Myocardial infarction
  • Myocardial ischemia–reperfusion
  • Permanent ligation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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