A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells

Medicine and Dentistry

• Cells 100%
• Cancer Cell 100%
• Prostate Cancer 100%
• Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase 100%
• Redox Signalling 100%
• Radiosensitization 100%
• Parthenolide 100%
• Signal Transduction 100%
• Oxidative Stress 50%
• Reactive Oxygen Species 50%
• Stress 20%
• Malignant Neoplasm 10%
• Antioxidant 10%
• Homeostasis 10%
• down Regulation 10%
• Phosphoinositide 3-Kinase 10%
• Glutathione 10%
• Manganese Superoxide Dismutase 10%
• Adaptive Response 10%
• Catalase 10%
• Antioxidant Capacity 10%
• Sensitization 10%
• Cell Killing 10%
• Antioxidant Enzyme 10%
• Thiol 10%
• Disulfide 10%
• Phosphorylation 10%
• Sesquiterpene Lactone 10%
• Thioredoxin 10%

Biochemistry, Genetics and Molecular Biology

• Signal Transduction 100%
• NAD(P)H Oxidase 100%
• Cancer Cell 100%
• Oxidative Stress 100%
• Species 100%
• Radiosensitization 100%
• Radiation 40%
• Stress 40%
• Phosphorylation 20%
• Manganese 20%
• Disulfide 20%
• Catalase 20%
• Antioxidant Enzyme 20%
• Adaptive Response 20%
• Homeostasis 20%
• down Regulation 20%
• Sensitization 20%
• Cell Killing 20%
• Superoxide Dismutase 20%
• Phosphoinositide 3-Kinase 20%
• Oxidation 20%
• Glutathione 20%
• Thiol 20%
• Thioredoxin 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Prostate Cancer 100%
• Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase 100%
• Parthenolide 100%
• Reactive Oxygen Metabolite 83%
• Malignant Neoplasm 66%
• Antioxidant 33%
• Antioxidant Capacity 16%
• Disulfide 16%
• Sensitization 16%
• Phosphatidylinositol 3 Kinase 16%
• Manganese Superoxide Dismutase 16%
• Glutathione 16%
• Enzymes 16%
• Catalase 16%
• Sesquiterpene Lactone 16%
• Thioredoxin 16%
• Thiol 16%