Cerebrovascular pathologies other than frank infarctions are commonly seen in aged brains. Here, we focus on multi-lumen vascular profiles (MVPs), which are characterized by multiple vessel lumens enclosed in a single vascular channel. Little information exists on the prevalence, risk factors, and co-pathologies of MVPs. Therefore, we used samples and data from the University of Kentucky Alzheimer’s Disease Research Center (n = 91), the University of Kentucky Pathology Department (n = 31), and the University of Pittsburgh Pathology Department (n = 4) to study MVPs. Age at death was correlated with MVP density in the frontal neocortex, Brodmann Area 9 (r = 0.51; p < 0.0001). Exploratory analyses were performed to evaluate the association between conventional vascular risk factors (e.g., hypertension, diabetes), cardiovascular diseases (e.g., heart attack, arrhythmia), and cerebrovascular disease (e.g., stroke); the only nominal association with MVP density was a self-reported history of brain trauma (Prevalence Ratio = 2.1; 95 CI 1.1–3.9, before correcting for multiple comparisons). No specific associations were detected between neuropathological (e.g., brain arteriolosclerosis) or genetic (e.g., APOE) variables and MVP density. Using a tissue clearing method called SeeDB, we provide 3-dimensional images of MVPs in brain tissue. We conclude that MVPs are an age-related brain pathology and more work is required to identify their clinical-pathological correlation and associated risk factors.

Original languageEnglish
Article number138
JournalActa neuropathologica communications
Issue number1
StatePublished - Dec 2023

Bibliographical note

Funding Information:
This work was supported by the following National Institute of Health Grants: F30 NS090714-01A1, R01 AG038651, R01 AG042419, T32 AG000242, K25 AG043546, T32 AG078110, P30 AG066468, R21AG066865, and P30 AG072946.

Publisher Copyright:
© 2023, BioMed Central Ltd., part of Springer Nature.


  • Endothelial
  • SVD
  • Senescence
  • Small vessel disease
  • TBI
  • VCID
  • VTE

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'A neuropathologic feature of brain aging: multi-lumen vascular profiles'. Together they form a unique fingerprint.

Cite this