A new furan carboxamide and two potential precursors from a terrestrial streptomycete

Humaira Naureen, Michel Feussi Tala, Khaled A. Shaaban, Mohamed Shaaban, Anja Schüffler, Hartmut Laatsch

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Three new bioactive metabolites, 1,6-dihydroxy-2-methyl-heptan-4-one (1), 4-hydroxy-1-(2-methyl-oxiranyl)-pentan-2-one (2), and 2-(2-hydroxy-propyl)-4-methylfuran-3-carboxylic acid amide (3) were isolated from the terrestrial Streptomyces sp. isolate ANK245, along with the new microbial constituent p-vinylanisol (4a) and the known metabolites p-vinyl-phenol (4b) and phenethyl alcohol. Analysis of the nonpolar part of the extract by gas chromatography/mass spectrometry (GC-MS) provided further evidence for tetradecanoic acid, 9-octadecenoic acid, hexadecanoic acid, 2-methoxy-4-vinylphenol (4c), 4-hydroxy-3-methoxy-benzaldehyde, o-hydroxybiphenyl, and 1,5,9-trimethyl-4,8,13-cyclotetradecatrien-1,3-diol (5). Structures 1-3 of the new compounds were elucidated by nuclear magnetic resonance (NMR) and NMR spectroscopy, but mass spectrometry (MS) techniques and their absolute configuration were determined by density functional theory (DFT) calculations and Mosher derivatisation. Their antimicrobial and cytotoxic activities were evaluated in comparison with the crude bacterial extract.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalZeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
Issue number3
StatePublished - 2017


  • Cd calculations
  • Furan carboxamide
  • Terrestrial Streptomyces sp

ASJC Scopus subject areas

  • Chemistry (all)


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