A new, one-carbon homologation procedure for the conversion of ketones to-hydroxy aldehydes involves two steps: (1) Darzens condensation of ketones with chloromethyl phenyl sulfone; (2) ring opening of the intermediate α,β-epoxy sulfones with hydroxide ion generated by adding water to potassium tert-butoxide. This new sequence proceeds in good overall yields and with high stereoselectivity.
|Number of pages||5|
|Journal||Journal of Organic Chemistry|
|State||Published - Nov 1984|
ASJC Scopus subject areas
- Organic Chemistry