TY - JOUR
T1 - A new role for polyketides
AU - Rohr, Jürgen
PY - 2000/8/18
Y1 - 2000/8/18
N2 - A toxic determinant of the human skin disease the Buruli ulcer, which is caused by Mycobacterium ulcerans, has been identified for the first time as containing two polyketides. The novel structures of these twelve-membered macrolides (one of which is shown) reveal an unusual biosynthesis, in which two type 1 polyketide synthases (PKS) have to be involved. There is also evidence that the polyketide toxin might represent the first of a family of virulence factors associated with other mycobacterial diseases, such as leprosy and tuberculosis.
AB - A toxic determinant of the human skin disease the Buruli ulcer, which is caused by Mycobacterium ulcerans, has been identified for the first time as containing two polyketides. The novel structures of these twelve-membered macrolides (one of which is shown) reveal an unusual biosynthesis, in which two type 1 polyketide synthases (PKS) have to be involved. There is also evidence that the polyketide toxin might represent the first of a family of virulence factors associated with other mycobacterial diseases, such as leprosy and tuberculosis.
KW - Biosynthesis
KW - Macrolides
KW - Natural products
KW - Polyketides
KW - Toxins
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U2 - 10.1002/1521-3773(20000818)39:16<2847::AID-ANIE2847>3.0.CO;2-0
DO - 10.1002/1521-3773(20000818)39:16<2847::AID-ANIE2847>3.0.CO;2-0
M3 - Review article
AN - SCOPUS:0034682909
SN - 1433-7851
VL - 39
SP - 2847
EP - 2849
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 16
ER -
