(Equation presented) The three-carbon α,α′-annulation of a sterically hindered cyclic β-keto ester can be achieved by alkynylation with 3,3-dietnoxypropyne, syn reduction of the alkyne with Co 2(CO)8 and Et3SiH, and an intramolecular aldol reaction. The method is potentially useful for the synthesis of nemorosone, hyperforin, and other polycyclic polyprenylated acylphloroglucinols.
|Number of pages||3|
|State||Published - Nov 27 2003|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry