A new type of DNA “light-switch”: A dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

Erin Wachter, Brock S. Howerton, Emily C. Hall, Sean Parkin, Edith C. Glazer

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Ru(bpy)2dppz, a well studied “light-switch” metal complex, transforms into a photochemical “light-switch” and DNA damaging agent by incorporating structural strain. This distorted compound is photoreactive and ejects a ligand upon binding duplex and G-quadruplex DNA, producing a reactive metal center that metalates the DNA.

Original languageEnglish
Pages (from-to)311-313
Number of pages3
JournalChemical Communications
Volume50
Issue number3
DOIs
StatePublished - Dec 3 2014

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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