A new type of DNA “light-switch”: A dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

Erin Wachter; Brock S. Howerton; Emily C. Hall; Sean Parkin; Edith C. Glazer

doi:10.1039/c3cc47269h

A new type of DNA “light-switch”: A dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

Erin Wachter
, Brock S. Howerton
, Emily C. Hall
, Sean Parkin
, Edith C. Glazer

Chemistry

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Ru(bpy)₂dppz, a well studied “light-switch” metal complex, transforms into a photochemical “light-switch” and DNA damaging agent by incorporating structural strain. This distorted compound is photoreactive and ejects a ligand upon binding duplex and G-quadruplex DNA, producing a reactive metal center that metalates the DNA.

Original language	English
Pages (from-to)	311-313
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	3
DOIs	https://doi.org/10.1039/c3cc47269h
State	Published - Dec 3 2014

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c3cc47269h

Cite this

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title = "A new type of DNA {\textquotedblleft}light-switch{\textquotedblright}: A dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA",

abstract = "Ru(bpy)2dppz, a well studied {\textquotedblleft}light-switch{\textquotedblright} metal complex, transforms into a photochemical {\textquotedblleft}light-switch{\textquotedblright} and DNA damaging agent by incorporating structural strain. This distorted compound is photoreactive and ejects a ligand upon binding duplex and G-quadruplex DNA, producing a reactive metal center that metalates the DNA.",

author = "Erin Wachter and Howerton, \{Brock S.\} and Hall, \{Emily C.\} and Sean Parkin and Glazer, \{Edith C.\}",

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AU - Wachter, Erin

AU - Howerton, Brock S.

AU - Hall, Emily C.

AU - Parkin, Sean

AU - Glazer, Edith C.

PY - 2014/12/3

Y1 - 2014/12/3

N2 - Ru(bpy)2dppz, a well studied “light-switch” metal complex, transforms into a photochemical “light-switch” and DNA damaging agent by incorporating structural strain. This distorted compound is photoreactive and ejects a ligand upon binding duplex and G-quadruplex DNA, producing a reactive metal center that metalates the DNA.

AB - Ru(bpy)2dppz, a well studied “light-switch” metal complex, transforms into a photochemical “light-switch” and DNA damaging agent by incorporating structural strain. This distorted compound is photoreactive and ejects a ligand upon binding duplex and G-quadruplex DNA, producing a reactive metal center that metalates the DNA.

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M3 - Article

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AN - SCOPUS:84889256925

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JO - Chemical Communications

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A new type of DNA “light-switch”: A dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

Abstract

ASJC Scopus subject areas

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