A new type of DNA “light-switch”: A dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

Erin Wachter; Brock S. Howerton; Emily C. Hall; Sean Parkin; Edith C. Glazer

doi:10.1039/c3cc47269h

A new type of DNA “light-switch”: A dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

Erin Wachter, Brock S. Howerton, Emily C. Hall, Sean Parkin, Edith C. Glazer

Chemistry

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Ru(bpy)₂dppz, a well studied “light-switch” metal complex, transforms into a photochemical “light-switch” and DNA damaging agent by incorporating structural strain. This distorted compound is photoreactive and ejects a ligand upon binding duplex and G-quadruplex DNA, producing a reactive metal center that metalates the DNA.

Original language	English
Pages (from-to)	311-313
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	3
DOIs	https://doi.org/10.1039/c3cc47269h
State	Published - Dec 3 2014

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "Ru(bpy)2dppz, a well studied “light-switch” metal complex, transforms into a photochemical “light-switch” and DNA damaging agent by incorporating structural strain. This distorted compound is photoreactive and ejects a ligand upon binding duplex and G-quadruplex DNA, producing a reactive metal center that metalates the DNA.",

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AU - Parkin, Sean

AU - Glazer, Edith C.

PY - 2014/12/3

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AB - Ru(bpy)2dppz, a well studied “light-switch” metal complex, transforms into a photochemical “light-switch” and DNA damaging agent by incorporating structural strain. This distorted compound is photoreactive and ejects a ligand upon binding duplex and G-quadruplex DNA, producing a reactive metal center that metalates the DNA.

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A new type of DNA “light-switch”: A dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

Abstract

ASJC Scopus subject areas

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