A not-so-simple twist of fate

Alexandra F. Long; Tim Stearns

doi:10.1016/j.devcel.2021.02.003

A not-so-simple twist of fate

Alexandra F. Long, Tim Stearns

Biology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Multiciliated cells are considered terminally differentiated, yet tissues bearing them are remodeled during development and after injury. In this issue of Developmental Cell, Tasca et al. (2021) show that multiciliated epithelial cells are lost via two different Notch-dependent processes, apoptosis and transdifferentiation, during developmental remodeling of the Xenopus epidermis.Multiciliated cells are considered terminally differentiated, yet tissues bearing them are remodeled during development and after injury. In this issue of Developmental Cell, Tasca et al. (2021) show that multiciliated epithelial cells are lost via two different Notch-dependent processes, apoptosis and transdifferentiation, during developmental remodeling of the Xenopus epidermis.

Original language	English
Pages (from-to)	402-404
Number of pages	3
Journal	Developmental Cell
Volume	56
Issue number	4
DOIs	https://doi.org/10.1016/j.devcel.2021.02.003
State	Published - Feb 22 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc.

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2021.02.003

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AB - Multiciliated cells are considered terminally differentiated, yet tissues bearing them are remodeled during development and after injury. In this issue of Developmental Cell, Tasca et al. (2021) show that multiciliated epithelial cells are lost via two different Notch-dependent processes, apoptosis and transdifferentiation, during developmental remodeling of the Xenopus epidermis.Multiciliated cells are considered terminally differentiated, yet tissues bearing them are remodeled during development and after injury. In this issue of Developmental Cell, Tasca et al. (2021) show that multiciliated epithelial cells are lost via two different Notch-dependent processes, apoptosis and transdifferentiation, during developmental remodeling of the Xenopus epidermis.

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A not-so-simple twist of fate

Abstract

Bibliographical note

ASJC Scopus subject areas

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