TY - JOUR
T1 - A novel approach to the study of hypoxia-ischemia-induced clinical and subclinical seizures in the neonatal rat
AU - Cuaycong, M.
AU - Engel, M.
AU - Weinstein, S. L.
AU - Salmon, E.
AU - Perlman, J. M.
AU - Sunderam, S.
AU - Vannucci, S. J.
PY - 2011/10
Y1 - 2011/10
N2 - Perinatal hypoxic-ischemic encephalopathy (HIE) is a major cause of acute mortality and chronic neurologic morbidity in infants and children. HIE is the most common cause of neonatal seizures, and seizure activity in neonates can be clinical, with both EEG and behavioral symptoms, subclinical with only EEG activity, or just behavioral. The accurate detection of these different seizure manifestations and the extent to which they differ in their effects on the neonatal brain continues to be a concern in neonatal medicine. Most experimental studies of the interaction between hypoxia-ischemia (HI) and seizures have utilized a chemical induction of seizures, which may be less clinically relevant. Here, we expanded our model of unilateral cerebral HI in the immature rat to include video EEG and electromyographic recording before, during and after HI in term-equivalent postnatal-day-12 rats. We observed that immature rats display both clinical and subclinical seizures during the period of HI, and that the total number of seizures and time to first seizure correlate with the extent of tissue damage. We also tested the feasibility of developing an automated seizure detection algorithm for the unbiased detection and characterization of the different types of seizure activity observed in this model.
AB - Perinatal hypoxic-ischemic encephalopathy (HIE) is a major cause of acute mortality and chronic neurologic morbidity in infants and children. HIE is the most common cause of neonatal seizures, and seizure activity in neonates can be clinical, with both EEG and behavioral symptoms, subclinical with only EEG activity, or just behavioral. The accurate detection of these different seizure manifestations and the extent to which they differ in their effects on the neonatal brain continues to be a concern in neonatal medicine. Most experimental studies of the interaction between hypoxia-ischemia (HI) and seizures have utilized a chemical induction of seizures, which may be less clinically relevant. Here, we expanded our model of unilateral cerebral HI in the immature rat to include video EEG and electromyographic recording before, during and after HI in term-equivalent postnatal-day-12 rats. We observed that immature rats display both clinical and subclinical seizures during the period of HI, and that the total number of seizures and time to first seizure correlate with the extent of tissue damage. We also tested the feasibility of developing an automated seizure detection algorithm for the unbiased detection and characterization of the different types of seizure activity observed in this model.
KW - Hypoxic-ischemic brain damage
KW - Seizure detection algorithm
KW - Video electroencephalography
UR - http://www.scopus.com/inward/record.url?scp=80155172486&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80155172486&partnerID=8YFLogxK
U2 - 10.1159/000331646
DO - 10.1159/000331646
M3 - Article
C2 - 21952605
AN - SCOPUS:80155172486
SN - 0378-5866
VL - 33
SP - 241
EP - 250
JO - Developmental Neuroscience
JF - Developmental Neuroscience
IS - 3-4
ER -