A novel enzootic nasal tumor virus circulating in goats from Southern China

Shao Lun Zhai, Dian Hong Lv, Zhi Hong Xu, Jie Shi Yu, Xiao Hui Wen, He Zhang, Qin Ling Chen, Chun Ling Jia, Xiu Rong Zhou, Qi Zhai, Feng Li, Patrick C.Y. Woo, Susanna K.P. Lau, Dan Wang, Wen Kang Wei

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Enzootic nasal tumor virus (ENTV) has two types, ENTV-1 in sheep and ENTV-2 in goats, respectively. In China, the incidence of ENTV-2 related diseases has increased year by year. In this study, we reported an outbreak of ENTV-2 in a commercial goat farm in Qingyuan city, Guangdong province, southern China. A full-length genome of ENTV-2 (designated GDQY2017), with 7479 base pairs, was sequenced. Although GDQY2017 shared the highest nucleotide identity with a Chinese ENTV-2 isolate (ENTV-2CHN4, GenBank accession number KU258873), it possesses distinct genome characteristics undescribed, including a non-continuous 21-nucleotide insertion in the gag gene and a non-continuous 12-nucleotide deletion in the env gene. Notably, most of these indel nucleotide sequences were originated from a Chinese jaagsiekte sheep retrovirus (JSRV) isolate (GenBank accession number DQ838494). In the gag and env genes, GDQY2017 was phylogenetically related to those Chinese ENTV-2 isolates and a Chinese JSRV isolate (DQ838494). For GDQY2017-like viruses, more surveillance work should be made to explain their pathogenicity in goat herds. To our knowledge, this study represents the first to demonstrate the circulating pattern of ENTV-2 in Guangdong province, China, which will help to better understand the epidemiology and genetic diversity of ENTV-2.

Original languageEnglish
Article number956
Issue number10
StatePublished - Oct 17 2019

Bibliographical note

Funding Information:
Funding: This research was funded by two grants (Grant nos. 2017A040403061 and 2019B020217002) from Guangdong Provincial Department of Science and Technology, and two grants (Disciplinary Team Construction Program, Grant no. 201634TD and Jinying’s Star Talent Program, Grant no. 201803) from Guangdong Academy of Agricultural Sciences.

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.


  • ENTV-2
  • Enzootic nasal tumor virus
  • Genetic diversity
  • Goats
  • Guangdong province
  • Novel variation

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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