TY - JOUR
T1 - A novel hepacivirus inwild rodents from South America
AU - de Souza, William Marciel
AU - Fumagalli, Marcílio Jorge
AU - Sabino-Santos, Gilberto
AU - Maia, Felipe Gonçalves Motta
AU - Modha, Sejal
AU - Nunes, Márcio Roberto Teixeira
AU - Murcia, Pablo Ramiro
AU - Figueiredo, Luiz Tadeu Moraes
N1 - Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019/3
Y1 - 2019/3
N2 - The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus has been identified in the South American continent. Here, we describe an unknown hepacivirus discovered during a metagenomic screen in Akodon montensis, Calomys tener, Oligoryzomys nigripes, Necromys lasiurus, and Mus musculus from São Paulo State, Brazil. Molecular detection of this novel hepacivirus by RT-PCR showed a frequency of 11.11% (2/18) in Oligoryzomys nigripes. This is the first identification of hepavivirus in sigmondonine rodents and in rodents from South America. In sum, our results expand the host range, viral diversity, and geographical distribution of the Hepacivirus genus.
AB - The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus has been identified in the South American continent. Here, we describe an unknown hepacivirus discovered during a metagenomic screen in Akodon montensis, Calomys tener, Oligoryzomys nigripes, Necromys lasiurus, and Mus musculus from São Paulo State, Brazil. Molecular detection of this novel hepacivirus by RT-PCR showed a frequency of 11.11% (2/18) in Oligoryzomys nigripes. This is the first identification of hepavivirus in sigmondonine rodents and in rodents from South America. In sum, our results expand the host range, viral diversity, and geographical distribution of the Hepacivirus genus.
KW - Flaviviridae
KW - Hepacivirus
KW - Viral hepatitis
UR - http://www.scopus.com/inward/record.url?scp=85063713197&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063713197&partnerID=8YFLogxK
U2 - 10.3390/v11030297
DO - 10.3390/v11030297
M3 - Article
C2 - 30909631
AN - SCOPUS:85063713197
SN - 1999-4915
VL - 11
JO - Viruses
JF - Viruses
IS - 3
M1 - 297
ER -