A novel microreactor approach for analysis of ketones and aldehydes in breath

Xiao An Fu; Mingxiao Li; Souvik Biswas; Michael H. Nantz; Richard M. Higashi

doi:10.1039/c1an15618g

A novel microreactor approach for analysis of ketones and aldehydes in breath

Xiao An Fu, Mingxiao Li, Souvik Biswas, Michael H. Nantz, Richard M. Higashi

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

We report a fabricated microreactor with thousands of micropillars in channels. Each micropillar surface is chemically functionalized to selectively preconcentrate gaseous ketones and aldehydes of exhaled breath and to enhance ultra-trace, rapid analysis by direct-infusion Fourier transform-ion cyclotron resonance (FT-ICR) mass spectrometry (MS). The micropillar reactive coating contains the quaternary ammonium aminooxy salt 2-(aminooxy)ethyl-N,N,N- trimethylammonium iodide (ATM) for capturing trace carbonyl VOCs by means of an oximation reaction. We demonstrate the utility of this approach for detection of C₁ to C₁₂ aldehydes and ketones in exhaled breath, but the approach is applicable to any gaseous sample.

Original language	English
Pages (from-to)	4662-4666
Number of pages	5
Journal	Analyst
Volume	136
Issue number	22
DOIs	https://doi.org/10.1039/c1an15618g
State	Published - Nov 21 2011

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Environmental Chemistry
Spectroscopy
Electrochemistry

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abstract = "We report a fabricated microreactor with thousands of micropillars in channels. Each micropillar surface is chemically functionalized to selectively preconcentrate gaseous ketones and aldehydes of exhaled breath and to enhance ultra-trace, rapid analysis by direct-infusion Fourier transform-ion cyclotron resonance (FT-ICR) mass spectrometry (MS). The micropillar reactive coating contains the quaternary ammonium aminooxy salt 2-(aminooxy)ethyl-N,N,N- trimethylammonium iodide (ATM) for capturing trace carbonyl VOCs by means of an oximation reaction. We demonstrate the utility of this approach for detection of C1 to C12 aldehydes and ketones in exhaled breath, but the approach is applicable to any gaseous sample.",

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AU - Fu, Xiao An

AU - Li, Mingxiao

AU - Biswas, Souvik

AU - Nantz, Michael H.

AU - Higashi, Richard M.

PY - 2011/11/21

Y1 - 2011/11/21

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AB - We report a fabricated microreactor with thousands of micropillars in channels. Each micropillar surface is chemically functionalized to selectively preconcentrate gaseous ketones and aldehydes of exhaled breath and to enhance ultra-trace, rapid analysis by direct-infusion Fourier transform-ion cyclotron resonance (FT-ICR) mass spectrometry (MS). The micropillar reactive coating contains the quaternary ammonium aminooxy salt 2-(aminooxy)ethyl-N,N,N- trimethylammonium iodide (ATM) for capturing trace carbonyl VOCs by means of an oximation reaction. We demonstrate the utility of this approach for detection of C1 to C12 aldehydes and ketones in exhaled breath, but the approach is applicable to any gaseous sample.

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A novel microreactor approach for analysis of ketones and aldehydes in breath

Abstract

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