A novel perspective on stem cell homing and mobilization: Review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients

M. Z. Ratajczak; C. H. Kim; A. Abdel-Latif; G. Schneider; M. Kucia; A. J. Morris; M. J. Laughlin; J. Ratajczak

doi:10.1038/leu.2011.242

A novel perspective on stem cell homing and mobilization: Review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients

M. Z. Ratajczak
, C. H. Kim
, A. Abdel-Latif
, G. Schneider
, M. Kucia
, A. J. Morris
, M. J. Laughlin
, J. Ratajczak

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

93 Scopus citations

Abstract

Hematopoietic stem progenitor cells (HSPCs) respond robustly to α-chemokine stromal-derived factor-1 (SDF-1) gradients, and blockage of CXCR4, a seven-transmembrane-spanning G αI-protein-coupled SDF-1 receptor, mobilizes HSPCs into peripheral blood. Although the SDF-1-CXCR4 axis has an unquestionably important role in the retention of HSPCs in bone marrow (BM), new evidence shows that, in addition to SDF-1, the migration of HSPCs is directed by gradients of the bioactive lipids sphingosine-1 phosphate and ceramide-1 phosphate. Furthermore, the SDF-1 gradient may be positively primed/modulated by cationic peptides (C3a anaphylatoxin and cathelicidin) and, as previously demonstrated, HSPCs respond robustly even to very low SDF-1 gradients in the presence of priming factors. In this review, we discuss the role of bioactive lipids in stem cell trafficking and the consequences of HSPC priming by cationic peptides. Together, these phenomena support a picture in which the SDF-1-CXCR4 axis modulates homing, BM retention and mobilization of HSPCs in a more complex way than previously envisioned.

Original language	English
Pages (from-to)	63-72
Number of pages	10
Journal	Leukemia
Volume	26
Issue number	1
DOIs	https://doi.org/10.1038/leu.2011.242
State	Published - Jan 2012

Bibliographical note

Funding Information:
This work was supported by NIH R01 DK074720, EU structural funds, KBN Grant (N N401 024536), Innovative Economy Operational Program POIG.01.01.02-00-109/09-01 and the Henry M and Stella M Hoenig Endowment (to MZR).

Funding

This work was supported by NIH R01 DK074720, EU structural funds, KBN Grant (N N401 024536), Innovative Economy Operational Program POIG.01.01.02-00-109/09-01 and the Henry M and Stella M Hoenig Endowment (to MZR).

Funders	Funder number
Polish State Committee for Scientific Research (KBN)	POIG.01.01.02-00-109/09-01, N N401 024536
National Institutes of Health (NIH)	R01 DK074720
National Institute of General Medical Sciences	P20GM103527
European Commission

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

C1P
C3a
CXCR4
S1P
SDF-1
cathelicidin

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Access to Document

10.1038/leu.2011.242

Cite this

Ratajczak, M. Z., Kim, C. H., Abdel-Latif, A., Schneider, G., Kucia, M., Morris, A. J., Laughlin, M. J., & Ratajczak, J. (2012). A novel perspective on stem cell homing and mobilization: Review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients. Leukemia, 26(1), 63-72. https://doi.org/10.1038/leu.2011.242

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title = "A novel perspective on stem cell homing and mobilization: Review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients",

abstract = "Hematopoietic stem progenitor cells (HSPCs) respond robustly to α-chemokine stromal-derived factor-1 (SDF-1) gradients, and blockage of CXCR4, a seven-transmembrane-spanning G αI-protein-coupled SDF-1 receptor, mobilizes HSPCs into peripheral blood. Although the SDF-1-CXCR4 axis has an unquestionably important role in the retention of HSPCs in bone marrow (BM), new evidence shows that, in addition to SDF-1, the migration of HSPCs is directed by gradients of the bioactive lipids sphingosine-1 phosphate and ceramide-1 phosphate. Furthermore, the SDF-1 gradient may be positively primed/modulated by cationic peptides (C3a anaphylatoxin and cathelicidin) and, as previously demonstrated, HSPCs respond robustly even to very low SDF-1 gradients in the presence of priming factors. In this review, we discuss the role of bioactive lipids in stem cell trafficking and the consequences of HSPC priming by cationic peptides. Together, these phenomena support a picture in which the SDF-1-CXCR4 axis modulates homing, BM retention and mobilization of HSPCs in a more complex way than previously envisioned.",

keywords = "C1P, C3a, CXCR4, S1P, SDF-1, cathelicidin",

author = "Ratajczak, \{M. Z.\} and Kim, \{C. H.\} and A. Abdel-Latif and G. Schneider and M. Kucia and Morris, \{A. J.\} and Laughlin, \{M. J.\} and J. Ratajczak",

note = "Funding Information: This work was supported by NIH R01 DK074720, EU structural funds, KBN Grant (N N401 024536), Innovative Economy Operational Program POIG.01.01.02-00-109/09-01 and the Henry M and Stella M Hoenig Endowment (to MZR).",

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doi = "10.1038/leu.2011.242",

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Ratajczak, MZ, Kim, CH, Abdel-Latif, A, Schneider, G, Kucia, M, Morris, AJ, Laughlin, MJ & Ratajczak, J 2012, 'A novel perspective on stem cell homing and mobilization: Review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients', Leukemia, vol. 26, no. 1, pp. 63-72. https://doi.org/10.1038/leu.2011.242

A novel perspective on stem cell homing and mobilization: Review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients. / Ratajczak, M. Z.; Kim, C. H.; Abdel-Latif, A. et al.
In: Leukemia, Vol. 26, No. 1, 01.2012, p. 63-72.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - A novel perspective on stem cell homing and mobilization

T2 - Review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients

AU - Ratajczak, M. Z.

AU - Kim, C. H.

AU - Abdel-Latif, A.

AU - Schneider, G.

AU - Kucia, M.

AU - Morris, A. J.

AU - Laughlin, M. J.

AU - Ratajczak, J.

N1 - Funding Information: This work was supported by NIH R01 DK074720, EU structural funds, KBN Grant (N N401 024536), Innovative Economy Operational Program POIG.01.01.02-00-109/09-01 and the Henry M and Stella M Hoenig Endowment (to MZR).

PY - 2012/1

Y1 - 2012/1

N2 - Hematopoietic stem progenitor cells (HSPCs) respond robustly to α-chemokine stromal-derived factor-1 (SDF-1) gradients, and blockage of CXCR4, a seven-transmembrane-spanning G αI-protein-coupled SDF-1 receptor, mobilizes HSPCs into peripheral blood. Although the SDF-1-CXCR4 axis has an unquestionably important role in the retention of HSPCs in bone marrow (BM), new evidence shows that, in addition to SDF-1, the migration of HSPCs is directed by gradients of the bioactive lipids sphingosine-1 phosphate and ceramide-1 phosphate. Furthermore, the SDF-1 gradient may be positively primed/modulated by cationic peptides (C3a anaphylatoxin and cathelicidin) and, as previously demonstrated, HSPCs respond robustly even to very low SDF-1 gradients in the presence of priming factors. In this review, we discuss the role of bioactive lipids in stem cell trafficking and the consequences of HSPC priming by cationic peptides. Together, these phenomena support a picture in which the SDF-1-CXCR4 axis modulates homing, BM retention and mobilization of HSPCs in a more complex way than previously envisioned.

AB - Hematopoietic stem progenitor cells (HSPCs) respond robustly to α-chemokine stromal-derived factor-1 (SDF-1) gradients, and blockage of CXCR4, a seven-transmembrane-spanning G αI-protein-coupled SDF-1 receptor, mobilizes HSPCs into peripheral blood. Although the SDF-1-CXCR4 axis has an unquestionably important role in the retention of HSPCs in bone marrow (BM), new evidence shows that, in addition to SDF-1, the migration of HSPCs is directed by gradients of the bioactive lipids sphingosine-1 phosphate and ceramide-1 phosphate. Furthermore, the SDF-1 gradient may be positively primed/modulated by cationic peptides (C3a anaphylatoxin and cathelicidin) and, as previously demonstrated, HSPCs respond robustly even to very low SDF-1 gradients in the presence of priming factors. In this review, we discuss the role of bioactive lipids in stem cell trafficking and the consequences of HSPC priming by cationic peptides. Together, these phenomena support a picture in which the SDF-1-CXCR4 axis modulates homing, BM retention and mobilization of HSPCs in a more complex way than previously envisioned.

KW - C1P

KW - C3a

KW - CXCR4

KW - S1P

KW - SDF-1

KW - cathelicidin

UR - https://www.scopus.com/pages/publications/84856733415

UR - https://www.scopus.com/pages/publications/84856733415#tab=citedBy

U2 - 10.1038/leu.2011.242

DO - 10.1038/leu.2011.242

M3 - Review article

C2 - 21886175

AN - SCOPUS:84856733415

SN - 0887-6924

VL - 26

SP - 63

EP - 72

JO - Leukemia

JF - Leukemia

IS - 1

ER -

A novel perspective on stem cell homing and mobilization: Review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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