A NOVEL PLASMA BASED BIOMARKER of Alzheimer'S DISEASE

Melissa A. Bradley-Whitman, Erin Abner, Bert C. Lynn, Mark A. Lovell

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Specific biomarkers in a readily accessible biological fluid, such as blood, could aid in the identification, characterization, validation, and routine monitoring of Alzheimer's disease (AD) progression. In the current study, levels of the previously described novel cerebrospinal fluid aberrant protein complex composed of prostaglandin-D-synthase (PDS) and transthyretin (TTR) were quantified in plasma by a custom two-probe sandwich ELISA and compared to amyloid-β (Aβ)1-42 as a standard plasma biomarker of AD. Plasma was analyzed from 140 probable AD subjects, 135 subjects with mild cognitive impairment (MCI), 74 normal control subjects (NC) prior to MCI transition, 23 diseased control (DC) subjects with either frontotemporal dementia or dementia with Lewy bodies, and 182 normal control (NC) subjects who did not progress to MCI or dementia. Levels of Aβ1-42 were significantly elevated in NC subjects prior to MCI conversion but significantly reduced in probable AD subjects compared to NC subjects. Similarly, levels of the PDS-TTR complex were significantly reduced in both MCI and probable AD subjects compared to NC subjects. Furthermore, levels of Aβ1-42 and the PDS-TTR complex were not significantly different in DC subjects compared to NC subjects. MMSE scores were weakly but significantly correlated with plasma levels of the PDSTTR complex and Aβ1-42. Trail B scores were weakly but significantly correlated with plasma levels of Aβ1-42. Comparison of receiver operating curves shows the PDS-TTR complex is comparable to Aβ1-42 in both MCI and probable AD subjects.

Original languageEnglish
Pages (from-to)761-771
Number of pages11
JournalJournal of Alzheimer's Disease
Volume47
Issue number3
DOIs
StatePublished - Aug 3 2015

Bibliographical note

Publisher Copyright:
© 2015 - IOS Press and the authors. All rights reserved.

Keywords

  • Alzheimer's disease
  • PDS-TTR complex
  • biomarker
  • plasma

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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