Abstract
The regioselective reductive demethylation of the O-methyldiosphenol functionality in the A ring of quassin (3) with chlorotrimethylsilane and sodium iodide furnished picrasin B (1). Swern oxidation of 1 furnished Δ2-picrasin B (2), and O-methylation of 2 regenerated quassin (3).
Original language | English |
---|---|
Pages (from-to) | 5985-5988 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 30 |
Issue number | 44 |
DOIs | |
State | Published - 1989 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry