A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study

Xueyan Zhao; Xin Geng; Vinodh Srinivasasainagendra; Ninad Chaudhary; Suzanne Judd; Virginia Wadley; Orlando M. Gutiérrez; Henry Wang; Ethan M. Lange; Leslie A. Lange; Daniel Woo; Frederick W. Unverzagt; Monika Safford; Mary Cushman; Nita Limdi; Rakale Quarells; Donna K. Arnett; Marguerite R. Irvin; Degui Zhi

doi:10.1186/s12920-018-0462-7

A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study

Xueyan Zhao
, Xin Geng
, Vinodh Srinivasasainagendra
, Ninad Chaudhary
, Suzanne Judd
, Virginia Wadley
, Orlando M. Gutiérrez
, Henry Wang
, Ethan M. Lange
, Leslie A. Lange
, Daniel Woo
, Frederick W. Unverzagt
, Monika Safford
, Mary Cushman
, Nita Limdi
, Rakale Quarells
, Donna K. Arnett
, Marguerite R. Irvin
, Degui Zhi

College of Public Health

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background: Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited. Results: In our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the first time in African Americans. Conclusion: Our cross-racial validation of GWAS findings provide additional evidence for the important roles of these loci in the disease process and may help identify genes especially important for future functional validation.

Original language	English
Article number	26
Journal	BMC Medical Genomics
Volume	12
DOIs	https://doi.org/10.1186/s12920-018-0462-7
State	Published - Jan 31 2019

Bibliographical note

Publisher Copyright:
© 2019 The Author(s).

Funding

The REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort is supported by a cooperative agreement U01 NS041588 from the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Service. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke or the National Institutes of Health. Representatives of the funding agency have been involved in the review of the manuscript but not directly involved in the collection, management, analysis or interpretation of the data. X.Z is supported by University of Alabama at Birmingham Statistical Genetics Post-Doctoral Training Grant (NIH T32HL072757). X.G. and D.Z. are partially supported by Agriculture and Food Research Initiative Competitive Grant no. 2015–67015-22975 from the USDA National Institute of Food and Agriculture (NIFA), and USDA Aquaculture Research Program Competitive Grant no. 2014–70007-22395. This work was also supported by 1RC4MD005964. Publication charges for this article have been funded by NIH R01HG010086.

Funders	Funder number
National Institutes of Health (NIH)	T32HL072757, 2015–67015-22975
National Institutes of Health (NIH)
U.S. Department of Health and Human Services
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council
National Center for Research Resources	M01RR000032
National Center for Research Resources
U.S. Department of Agriculture	R01HG010086, 1RC4MD005964, 2014–70007-22395
U.S. Department of Agriculture
US Department of Agriculture National Institute of Food and Agriculture, Agriculture and Food Research Initiative
University of Alabama

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

African Americans
Cardiovascular disease
Genetics
PheWAS

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1186/s12920-018-0462-7

Cite this

Zhao, X., Geng, X., Srinivasasainagendra, V., Chaudhary, N., Judd, S., Wadley, V., Gutiérrez, O. M., Wang, H., Lange, E. M., Lange, L. A., Woo, D., Unverzagt, F. W., Safford, M., Cushman, M., Limdi, N., Quarells, R., Arnett, D. K., Irvin, M. R., & Zhi, D. (2019). A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study. BMC Medical Genomics, 12, Article 26. https://doi.org/10.1186/s12920-018-0462-7

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abstract = "Background: Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited. Results: In our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the first time in African Americans. Conclusion: Our cross-racial validation of GWAS findings provide additional evidence for the important roles of these loci in the disease process and may help identify genes especially important for future functional validation.",

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author = "Xueyan Zhao and Xin Geng and Vinodh Srinivasasainagendra and Ninad Chaudhary and Suzanne Judd and Virginia Wadley and Guti{\'e}rrez, \{Orlando M.\} and Henry Wang and Lange, \{Ethan M.\} and Lange, \{Leslie A.\} and Daniel Woo and Unverzagt, \{Frederick W.\} and Monika Safford and Mary Cushman and Nita Limdi and Rakale Quarells and Arnett, \{Donna K.\} and Irvin, \{Marguerite R.\} and Degui Zhi",

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Zhao, X, Geng, X, Srinivasasainagendra, V, Chaudhary, N, Judd, S, Wadley, V, Gutiérrez, OM, Wang, H, Lange, EM, Lange, LA, Woo, D, Unverzagt, FW, Safford, M, Cushman, M, Limdi, N, Quarells, R, Arnett, DK, Irvin, MR & Zhi, D 2019, 'A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study', BMC Medical Genomics, vol. 12, 26. https://doi.org/10.1186/s12920-018-0462-7

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T1 - A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study

AU - Zhao, Xueyan

AU - Geng, Xin

AU - Srinivasasainagendra, Vinodh

AU - Chaudhary, Ninad

AU - Judd, Suzanne

AU - Wadley, Virginia

AU - Gutiérrez, Orlando M.

AU - Wang, Henry

AU - Lange, Ethan M.

AU - Lange, Leslie A.

AU - Woo, Daniel

AU - Unverzagt, Frederick W.

AU - Safford, Monika

AU - Cushman, Mary

AU - Limdi, Nita

AU - Quarells, Rakale

AU - Arnett, Donna K.

AU - Irvin, Marguerite R.

AU - Zhi, Degui

PY - 2019/1/31

Y1 - 2019/1/31

N2 - Background: Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited. Results: In our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the first time in African Americans. Conclusion: Our cross-racial validation of GWAS findings provide additional evidence for the important roles of these loci in the disease process and may help identify genes especially important for future functional validation.

AB - Background: Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited. Results: In our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the first time in African Americans. Conclusion: Our cross-racial validation of GWAS findings provide additional evidence for the important roles of these loci in the disease process and may help identify genes especially important for future functional validation.

KW - African Americans

KW - Cardiovascular disease

KW - Genetics

KW - PheWAS

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AN - SCOPUS:85060892965

SN - 1755-8794

VL - 12

JO - BMC Medical Genomics

JF - BMC Medical Genomics

M1 - 26

ER -

A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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