A pilot investigation on the effects of combination transcranial direct current stimulation and speed of processing cognitive remediation therapy on simulated driving behavior in older adults with HIV

C. N. Pope; D. Stavrinos; D. E. Vance; A. J. Woods; T. R. Bell; K. K. Ball; P. L. Fazeli

doi:10.1016/j.trf.2018.08.002

A pilot investigation on the effects of combination transcranial direct current stimulation and speed of processing cognitive remediation therapy on simulated driving behavior in older adults with HIV

C. N. Pope, D. Stavrinos, D. E. Vance, A. J. Woods, T. R. Bell, K. K. Ball, P. L. Fazeli

Health, Behavior, and Society

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Cognitive impairments seen in people living with HIV (PLWH) are associated with difficulties in everyday functioning, specifically driving. This study utilized speed of processing cognitive remediation therapy (SOP-CRT) with transcranial direct current stimulation (tDCS) to gauge the feasibility and impact on simulated driving. Thirty PLWH (M_age = 54.53, SD = 3.33) were randomly assigned to either: sham tDCS SOP-CRT or active tDCS SOP-CRT. Seven indicators of simulated driving performance and safety were obtained. Repeated measures ANOVAs controlling for driver's license status (valid and current license or expired/no license) revealed a large training effect on average driving speed. Participants who received active tDCS SOP-CRT showed a slower average driving speed (p = 0.020, d = 0.972) than those who received sham tDCS SOP-CRT. Non-significant small-to-medium effects were seen for driving violations, collisions, variability in lane positioning, and lane deviations. Combination tDCS SOP-CRT was found to increase indices of cautionary simulated driving behavior. Findings reveal a potential avenue of intervention and rehabilitation for improving driving safety among vulnerable at-risk populations, such as those aging with chronic disease.

Original language	English
Pages (from-to)	1061-1073
Number of pages	13
Journal	Transportation Research Part F: Traffic Psychology and Behaviour
Volume	58
DOIs	https://doi.org/10.1016/j.trf.2018.08.002
State	Published - Oct 2018

Bibliographical note

Funding Information:
This work was supported by funding from the Edward R. Roybal Center (P30 AG022838), and a NIH/NIA K-award (PI: Fazeli: 1 K99 AG 048762-01) titled “A Novel Neurorehabilitation Approach for Cognitive Aging with HIV”. A special thank you to the UAB Department of Psychology, UAB School of Nursing, and the Translational Research for Injury Prevention (TRIP) lab.

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

Brain simulation
Cognitive remediation therapy
Driving
HIV/AIDS
Neuromodulation
tDCS

ASJC Scopus subject areas

Civil and Structural Engineering
Automotive Engineering
Transportation
Applied Psychology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.trf.2018.08.002

Cite this

Pope, C. N., Stavrinos, D., Vance, D. E., Woods, A. J., Bell, T. R., Ball, K. K., & Fazeli, P. L. (2018). A pilot investigation on the effects of combination transcranial direct current stimulation and speed of processing cognitive remediation therapy on simulated driving behavior in older adults with HIV. Transportation Research Part F: Traffic Psychology and Behaviour, 58, 1061-1073. https://doi.org/10.1016/j.trf.2018.08.002

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abstract = "Cognitive impairments seen in people living with HIV (PLWH) are associated with difficulties in everyday functioning, specifically driving. This study utilized speed of processing cognitive remediation therapy (SOP-CRT) with transcranial direct current stimulation (tDCS) to gauge the feasibility and impact on simulated driving. Thirty PLWH (Mage = 54.53, SD = 3.33) were randomly assigned to either: sham tDCS SOP-CRT or active tDCS SOP-CRT. Seven indicators of simulated driving performance and safety were obtained. Repeated measures ANOVAs controlling for driver's license status (valid and current license or expired/no license) revealed a large training effect on average driving speed. Participants who received active tDCS SOP-CRT showed a slower average driving speed (p = 0.020, d = 0.972) than those who received sham tDCS SOP-CRT. Non-significant small-to-medium effects were seen for driving violations, collisions, variability in lane positioning, and lane deviations. Combination tDCS SOP-CRT was found to increase indices of cautionary simulated driving behavior. Findings reveal a potential avenue of intervention and rehabilitation for improving driving safety among vulnerable at-risk populations, such as those aging with chronic disease.",

keywords = "Brain simulation, Cognitive remediation therapy, Driving, HIV/AIDS, Neuromodulation, tDCS",

author = "Pope, {C. N.} and D. Stavrinos and Vance, {D. E.} and Woods, {A. J.} and Bell, {T. R.} and Ball, {K. K.} and Fazeli, {P. L.}",

note = "Funding Information: This work was supported by funding from the Edward R. Roybal Center (P30 AG022838), and a NIH/NIA K-award (PI: Fazeli: 1 K99 AG 048762-01) titled “A Novel Neurorehabilitation Approach for Cognitive Aging with HIV”. A special thank you to the UAB Department of Psychology, UAB School of Nursing, and the Translational Research for Injury Prevention (TRIP) lab. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

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Pope, CN, Stavrinos, D, Vance, DE, Woods, AJ, Bell, TR, Ball, KK & Fazeli, PL 2018, 'A pilot investigation on the effects of combination transcranial direct current stimulation and speed of processing cognitive remediation therapy on simulated driving behavior in older adults with HIV', Transportation Research Part F: Traffic Psychology and Behaviour, vol. 58, pp. 1061-1073. https://doi.org/10.1016/j.trf.2018.08.002

A pilot investigation on the effects of combination transcranial direct current stimulation and speed of processing cognitive remediation therapy on simulated driving behavior in older adults with HIV. / Pope, C. N.; Stavrinos, D.; Vance, D. E. et al.

In: Transportation Research Part F: Traffic Psychology and Behaviour, Vol. 58, 10.2018, p. 1061-1073.

Research output: Contribution to journal › Article › peer-review

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AU - Pope, C. N.

AU - Stavrinos, D.

AU - Vance, D. E.

AU - Woods, A. J.

AU - Bell, T. R.

AU - Ball, K. K.

AU - Fazeli, P. L.

N1 - Funding Information: This work was supported by funding from the Edward R. Roybal Center (P30 AG022838), and a NIH/NIA K-award (PI: Fazeli: 1 K99 AG 048762-01) titled “A Novel Neurorehabilitation Approach for Cognitive Aging with HIV”. A special thank you to the UAB Department of Psychology, UAB School of Nursing, and the Translational Research for Injury Prevention (TRIP) lab. Publisher Copyright: © 2018 Elsevier Ltd

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Pope CN, Stavrinos D, Vance DE, Woods AJ, Bell TR, Ball KK et al. A pilot investigation on the effects of combination transcranial direct current stimulation and speed of processing cognitive remediation therapy on simulated driving behavior in older adults with HIV. Transportation Research Part F: Traffic Psychology and Behaviour. 2018 Oct;58:1061-1073. doi: 10.1016/j.trf.2018.08.002

A pilot investigation on the effects of combination transcranial direct current stimulation and speed of processing cognitive remediation therapy on simulated driving behavior in older adults with HIV

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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