TY - JOUR
T1 - A poor metabolizer for cytochromes P450 2D6 and 2C19
T2 - A case report on antidepressant treatment
AU - Johnson, Maria
AU - Markham-Abedi, Courtney
AU - Susce, Margaret T.
AU - Murray-Carmichael, Elaina
AU - McCollum, Stuart
AU - De Leon, Jose
PY - 2006/10
Y1 - 2006/10
N2 - Scientific literature has never described a poor metabolizer for both the cytochrome P450 (CYP) 2D6 and the CYP 2C19. They are expected to be rare (<1% in different ethnic groups) and prone to adverse drug reactions with many antidepressants. In an ongoing pharmacogenetic study, after genotyping 1,576 subjects in three Kentucky state hospitals we have found one poor metabolizer for both CYP 2D6 and CYP 2C19, which corresponds to a prevalence of 0.06% (95% CI 0.01 to 0.36). The naturalistic antidepressant treatment of this poor metabolizer for both enzymes is described in this article. As genotyping reaches clinical practice, it will be interesting to prospectively establish whether mirtazapine is a reasonable choice as an antidepressant for these patients, as the data and this case suggest.
AB - Scientific literature has never described a poor metabolizer for both the cytochrome P450 (CYP) 2D6 and the CYP 2C19. They are expected to be rare (<1% in different ethnic groups) and prone to adverse drug reactions with many antidepressants. In an ongoing pharmacogenetic study, after genotyping 1,576 subjects in three Kentucky state hospitals we have found one poor metabolizer for both CYP 2D6 and CYP 2C19, which corresponds to a prevalence of 0.06% (95% CI 0.01 to 0.36). The naturalistic antidepressant treatment of this poor metabolizer for both enzymes is described in this article. As genotyping reaches clinical practice, it will be interesting to prospectively establish whether mirtazapine is a reasonable choice as an antidepressant for these patients, as the data and this case suggest.
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U2 - 10.1017/S1092852900014887
DO - 10.1017/S1092852900014887
M3 - Article
C2 - 17008819
AN - SCOPUS:33750017284
SN - 1092-8529
VL - 11
SP - 757
EP - 760
JO - CNS Spectrums
JF - CNS Spectrums
IS - 10
ER -