A potential role for alterations of zinc and zinc transport proteins in the progression of alzheimer's disease

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Abstract

Although multiple studies have suggested a role for alterations of zinc (Zn) and zinc transport (ZnT) proteins in the pathogenesis of Alzheimer's disease, the exact role of this essential trace element in the progression of the disease remains unclear. The following review discusses the normal role of Zn and ZnT proteins in brain and the potential effects of their alteration in the pathogenesis of Alzheimer's disease, particularly in the processing of the amyloid-β protein precursor and amyloid-β peptide generation and aggregation.

Original languageEnglish
Pages (from-to)471-483
Number of pages13
JournalJournal of Alzheimer's Disease
Volume16
Issue number3
DOIs
StatePublished - 2009

Keywords

  • Amyloid-β
  • Early Alzheimer's disease
  • Mild cognitive impairment
  • Zinc
  • Zinc transport proteins

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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